Selectin
From Proteopedia
(Difference between revisions)
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'''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain | '''Selectin''' or '''CD62''' are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain | ||
| - | and a number of concensus repeat units, a transmembranal domain and a intracellular domain. Three types of selectins are found: E-selectin found in endothelial cells; L-selectin found in leukocytes; P-selectin found in platelets. Selectins are involved in inflammation processes. The L-selectins on the surface of leukocytes bind to carbohydrates causing the cells to roll along the bleed vessel walls, slowing their motion and enabling them to enter the site of infection. | + | and a number of concensus repeat units, a transmembranal domain and a intracellular domain. Three types of selectins are found: '''E-selectin''' found in endothelial cells; '''L-selectin''' found in leukocytes; '''P-selectin''' found in platelets. Selectins are involved in inflammation processes. The L-selectins on the surface of leukocytes bind to carbohydrates causing the cells to roll along the bleed vessel walls, slowing their motion and enabling them to enter the site of infection. |
==3D structures of selectin== | ==3D structures of selectin== | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | + | ===P-selectin=== | |
[[1fsb]] – hCD62P EGF domain – human - NMR<br /> | [[1fsb]] – hCD62P EGF domain – human - NMR<br /> | ||
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[[4gxb]] – hCD62P intracellular domain + sorting nexin-17<br /> | [[4gxb]] – hCD62P intracellular domain + sorting nexin-17<br /> | ||
| - | + | ===L-selectin=== | |
[[3cfw]] – hCD62L EGF domain <br /> | [[3cfw]] – hCD62L EGF domain <br /> | ||
[[2lgf]] – hCD62L calmodulin-binding domain + calmodulin<br /> | [[2lgf]] – hCD62L calmodulin-binding domain + calmodulin<br /> | ||
| - | + | ===E-selectin=== | |
[[1esl]] – hCD62E EGF domain <br /> | [[1esl]] – hCD62E EGF domain <br /> | ||
[[1g1t]] – hCD62E EGF domain + tetrasaccharide<br /> | [[1g1t]] – hCD62E EGF domain + tetrasaccharide<br /> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:26, 20 August 2014
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