Shikimate kinase
From Proteopedia
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{{STRUCTURE_2dfn| PDB=2dfn | SIZE=350| SCENE= |right|CAPTION=Shikimate kinase complex with shikimate and ADP (stick model) [[2dfn]] }} | {{STRUCTURE_2dfn| PDB=2dfn | SIZE=350| SCENE= |right|CAPTION=Shikimate kinase complex with shikimate and ADP (stick model) [[2dfn]] }} | ||
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'''Shikimate kinase''' (SK) catalyzes the ATP-dependent phosphorylation of shikimate to produce shikimate 3-phosphate. It is part of the plant and bacteria pathway of synthesizing aromatic acids. SK inhibitors can be used as antimicrobial drugs. | '''Shikimate kinase''' (SK) catalyzes the ATP-dependent phosphorylation of shikimate to produce shikimate 3-phosphate. It is part of the plant and bacteria pathway of synthesizing aromatic acids. SK inhibitors can be used as antimicrobial drugs. | ||
Revision as of 09:42, 20 August 2014
Shikimate kinase (SK) catalyzes the ATP-dependent phosphorylation of shikimate to produce shikimate 3-phosphate. It is part of the plant and bacteria pathway of synthesizing aromatic acids. SK inhibitors can be used as antimicrobial drugs.
3D Structures of shikimate kinase
Updated on 20-August-2014
2g1j, 2iyt – MtSK – Mycobacterium tuberculosis
2pt5 – SK – Aquifex aeolicus
3nwj – SK – Arabidopsis thaliana
3trf – SK – Coxiella burnetii
3vaa – SK – Bacterioides thetaiotaomicron
1via – SK – Campylobacter jejuni
1zuh, 3hr7 – HpSK – Helicobacter pylori
3mrs – HpSK (mutant)
1shk – EchSK – Erwinia chrysanthemi
1e6c – EchSK (mutant)
1kag – SK – Escherichia coli
Shikimate kinase binary complex
1l4u, 1l4y, 1u8a, 2iyu, 2iyv, 2dft – MtSK + ADP
2iyw – MtSK + ATP
3baf – MtSK + AMPPNP
2shk – EchSK + ADP
1zui – HpSK + shikimate
3n2e – HpSK (mutant) + inhibitor
2g1k, 2iyr, 2iys, 2iyx – MtSK + shikimate
2iyy – MtSK + shikimate-3-phosphate
Shikimate kinase ternary complex
2iyz – MtSK + ADP + shikimate-3-phosphate
1we2, 2dfn, 2iyq – MtSK + ADP + shikimate
1zyu – MtSK + AMPPCP + shikimate
3muf – HpSK + ADP + shikimate-3-phosphate
