1dot
From Proteopedia
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| - | [[Image:1dot.gif|left|200px]] | + | [[Image:1dot.gif|left|200px]] |
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| - | '''CRYSTALLOGRAPHIC STRUCTURE OF DUCK OVOTRANSFERRIN AT 2.3 ANGSTROMS RESOLUTION''' | + | {{Structure |
| + | |PDB= 1dot |SIZE=350|CAPTION= <scene name='initialview01'>1dot</scene>, resolution 2.35Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene> and <scene name='pdbligand=CO3:CARBONATE ION'>CO3</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''CRYSTALLOGRAPHIC STRUCTURE OF DUCK OVOTRANSFERRIN AT 2.3 ANGSTROMS RESOLUTION''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1DOT is a [ | + | 1DOT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Anas_platyrhynchos Anas platyrhynchos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DOT OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of diferric duck ovotransferrin at 2.35 A resolution., Rawas A, Muirhead H, Williams J, Acta Crystallogr D Biol Crystallogr. 1996 Jul 1;52(Pt 4):631-40. PMID:[http:// | + | Structure of diferric duck ovotransferrin at 2.35 A resolution., Rawas A, Muirhead H, Williams J, Acta Crystallogr D Biol Crystallogr. 1996 Jul 1;52(Pt 4):631-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15299626 15299626] |
[[Category: Anas platyrhynchos]] | [[Category: Anas platyrhynchos]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: iron transport protein]] | [[Category: iron transport protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:41:55 2008'' |
Revision as of 08:41, 20 March 2008
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| , resolution 2.35Å | |||||||
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| Ligands: | , , and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTALLOGRAPHIC STRUCTURE OF DUCK OVOTRANSFERRIN AT 2.3 ANGSTROMS RESOLUTION
Overview
The structure of diferric duck ovotransferrin (DOT) has been determined and refined at a resolution of 2.35 A. The DOT structure, which contains two iron binding sites, is similar to the known transferrin and lactoferrin structures. The two iron-binding sites, one in the N-terminal lobe and one in the C-terminal lobe of the molecule, are similar but not identical. The main differences between the three known structures lie in the relative orientations of the N- and C-lobes with respect to each other. In the DOT structure the large aromatic side chain of Phe322 in the N-lobe packs against the conserved residue Gly387 in the C-lobe. This interaction is at the centre of the interface between the two lobes and could play a crucial role in determining their relative orientation. Other differences between the structures occur in the surface loops and in the peptide connecting the two lobes. The final crystallographic model consists of 5309 protein atoms (686 residues), two Fe(3+) ions, two (bi)carbonate ions and three carbohydrate moities. 318 water molecules have been added to the model. The final R factor is 0.22 for 25 400 observed reflections between 10 and 2.35 A resolution.
About this Structure
1DOT is a Single protein structure of sequence from Anas platyrhynchos. Full crystallographic information is available from OCA.
Reference
Structure of diferric duck ovotransferrin at 2.35 A resolution., Rawas A, Muirhead H, Williams J, Acta Crystallogr D Biol Crystallogr. 1996 Jul 1;52(Pt 4):631-40. PMID:15299626
Page seeded by OCA on Thu Mar 20 10:41:55 2008
Categories: Anas platyrhynchos | Single protein | Muirhead, H. | Rawas, A. | CO3 | FE | FUC | NAG | Iron transport protein
