1dqe
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1dqe.gif|left|200px]] | + | [[Image:1dqe.gif|left|200px]] |
| - | + | ||
| - | '''BOMBYX MORI PHEROMONE BINDING PROTEIN''' | + | {{Structure |
| + | |PDB= 1dqe |SIZE=350|CAPTION= <scene name='initialview01'>1dqe</scene>, resolution 1.8Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=BOM:HEXADECA-10,12-DIEN-1-OL'>BOM</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''BOMBYX MORI PHEROMONE BINDING PROTEIN''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1DQE is a [ | + | 1DQE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQE OCA]. |
==Reference== | ==Reference== | ||
| - | Sexual attraction in the silkworm moth: structure of the pheromone-binding-protein-bombykol complex., Sandler BH, Nikonova L, Leal WS, Clardy J, Chem Biol. 2000 Feb;7(2):143-51. PMID:[http:// | + | Sexual attraction in the silkworm moth: structure of the pheromone-binding-protein-bombykol complex., Sandler BH, Nikonova L, Leal WS, Clardy J, Chem Biol. 2000 Feb;7(2):143-51. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10662696 10662696] |
[[Category: Bombyx mori]] | [[Category: Bombyx mori]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 20: | Line 29: | ||
[[Category: helical bundle]] | [[Category: helical bundle]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:42:37 2008'' |
Revision as of 08:42, 20 March 2008
| |||||||
| , resolution 1.8Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
BOMBYX MORI PHEROMONE BINDING PROTEIN
Overview
BACKGROUND: Insects use volatile organic molecules to communicate messages with remarkable sensitivity and specificity. In one of the most studied systems, female silkworm moths (Bombyx mori) attract male mates with the pheromone bombykol, a volatile 16-carbon alcohol. In the male moth's antennae, a pheromone-binding protein conveys bombykol to a membrane-bound receptor on a nerve cell. The structure of the pheromone-binding protein, its binding and recognition of bombykol, and its full role in signal transduction are not known. RESULTS: The three-dimensional structure of the B. mori pheromone-binding protein with bound bombykol has been determined by X-ray diffraction at 1.8 A resolution. CONCLUSIONS: The pheromone binding protein of B. mori has six helices, and bombykol binds in a completely enclosed hydrophobic cavity formed by four antiparallel helices. Bombykol is bound in this cavity through numerous hydrophobic interactions, and sequence alignments suggest critical residues for specific pheromone binding.
About this Structure
1DQE is a Single protein structure of sequence from Bombyx mori. Full crystallographic information is available from OCA.
Reference
Sexual attraction in the silkworm moth: structure of the pheromone-binding-protein-bombykol complex., Sandler BH, Nikonova L, Leal WS, Clardy J, Chem Biol. 2000 Feb;7(2):143-51. PMID:10662696
Page seeded by OCA on Thu Mar 20 10:42:37 2008
