1dqy

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[[Image:1dqy.gif|left|200px]]<br /><applet load="1dqy" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1dqy.gif|left|200px]]
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caption="1dqy, resolution 1.83&Aring;" />
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'''CRYSTAL STRUCTURE OF ANTIGEN 85C FROM MYCOBACTERIUM TUBERCULOSIS WITH DIETHYL PHOSPHATE INHIBITOR'''<br />
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{{Structure
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|PDB= 1dqy |SIZE=350|CAPTION= <scene name='initialview01'>1dqy</scene>, resolution 1.83&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=DEP:DIETHYL+PHOSPHONATE'>DEP</scene> and <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF ANTIGEN 85C FROM MYCOBACTERIUM TUBERCULOSIS WITH DIETHYL PHOSPHATE INHIBITOR'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1DQY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with <scene name='pdbligand=DEP:'>DEP</scene> and <scene name='pdbligand=MRD:'>MRD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQY OCA].
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1DQY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQY OCA].
==Reference==
==Reference==
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Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines., Ronning DR, Klabunde T, Besra GS, Vissa VD, Belisle JT, Sacchettini JC, Nat Struct Biol. 2000 Feb;7(2):141-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10655617 10655617]
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Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines., Ronning DR, Klabunde T, Besra GS, Vissa VD, Belisle JT, Sacchettini JC, Nat Struct Biol. 2000 Feb;7(2):141-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10655617 10655617]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: protein structure initiative]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: psi]]
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[[Category: structural genomics]]
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[[Category: structural genomic]]
[[Category: tb structural genomics consortium]]
[[Category: tb structural genomics consortium]]
[[Category: tbsgc]]
[[Category: tbsgc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:19:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:42:56 2008''

Revision as of 08:43, 20 March 2008

Image:1dqy.gif


PDB ID 1dqy

Drag the structure with the mouse to rotate
, resolution 1.83Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF ANTIGEN 85C FROM MYCOBACTERIUM TUBERCULOSIS WITH DIETHYL PHOSPHATE INHIBITOR


Overview

The antigen 85 (ag85) complex, composed of three proteins (ag85A, B and C), is a major protein component of the Mycobacterium tuberculosis cell wall. Each protein possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity. The crystal structure of recombinant ag85C from M. tuberculosis, refined to a resolution of 1.5 A, reveals an alpha/beta-hydrolase polypeptide fold, and a catalytic triad formed by Ser 124, Glu 228 and His 260. ag85C complexed with a covalent inhibitor implicates residues Leu 40 and Met 125 as components of the oxyanion hole. A hydrophobic pocket and tunnel extending 21 A into the core of the protein indicates the location of a probable trehalose monomycolate binding site. Also, a large region of conserved surface residues among ag85A, B and C is a probable site for the interaction of ag85 proteins with human fibronectin.

About this Structure

1DQY is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines., Ronning DR, Klabunde T, Besra GS, Vissa VD, Belisle JT, Sacchettini JC, Nat Struct Biol. 2000 Feb;7(2):141-6. PMID:10655617

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