Tryptophan synthase

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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==TrpS α subunit==
+
===TrpS α subunit===
[[3vnd]] - TrpS α subunit – ''Shewanella frigidimarina''<br />
[[3vnd]] - TrpS α subunit – ''Shewanella frigidimarina''<br />
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[[2ekc]] - TrpS α subunit – ''Aquifex aeolicus''<br />
[[2ekc]] - TrpS α subunit – ''Aquifex aeolicus''<br />
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==TrpS β subunit==
+
''TrpS α binary complex''
 +
[[1wxj]] - TtTrpS α subunit + indole propanol phosphate<br />
 +
 +
===TrpS β subunit===
[[1x1q]] - TtTrpS β subunit – ''Thermus thermophilus''<br />
[[1x1q]] - TtTrpS β subunit – ''Thermus thermophilus''<br />
Line 29: Line 32:
[[4neg]] - TrpS β subunit – ''Bacillus anthracis''<br />
[[4neg]] - TrpS β subunit – ''Bacillus anthracis''<br />
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==TrpS α+β subunits==
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''TrpS β binary complex''
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[[1wdw]] - PfTrpS α + β subunits <br />
+
[[2dh5]] - EcTrpS β subunit + PLP<br />
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==TrpS binary complex==
+
===TrpS α+β subunits===
-
[[1wxj]] - TtTrpS α subunit + indole propanol phosphate<br />
+
[[1wdw]] - PfTrpS α + β subunits <br />
-
[[2dh5]] - EcTrpS β subunit + PLP<br />
+
 
 +
''TrpS α+β binary complex''
 +
[[1ttp]], [[1ttq]], [[1bks]], [[2wsy]], [[1kfk]] - StTrpS α + β + PLP – ''Salmonella typhimurium''<br />
[[1ttp]], [[1ttq]], [[1bks]], [[2wsy]], [[1kfk]] - StTrpS α + β + PLP – ''Salmonella typhimurium''<br />
[[1a5a]], [[1k8x]] - StTrpS α (mutant) + β + PLP<br />
[[1a5a]], [[1k8x]] - StTrpS α (mutant) + β + PLP<br />
Line 47: Line 52:
[[4hn4]], [[4hpj]], [[4hpx]], [[4ht3]], [[4kkx]] - TrpS α + β + inhibitor – ''Salmonella enterica''<br />
[[4hn4]], [[4hpj]], [[4hpx]], [[4ht3]], [[4kkx]] - TrpS α + β + inhibitor – ''Salmonella enterica''<br />
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==TrpS ternary complex with PLP and inhibitor==
+
''TrpS α+β ternary complex with PLP and inhibitor''
[[1a50]], [[1cw2]], [[1c9d]], [[1cx9]], [[1c8v]], [[1c29]], [[2cle]], [[2clh]], [[2cli]], [[2clk]], [[2cll]], [[2clm]], [[2clo]], [[2clf]] - StTrpS α + β + inhibitor + PLP<br />
[[1a50]], [[1cw2]], [[1c9d]], [[1cx9]], [[1c8v]], [[1c29]], [[2cle]], [[2clh]], [[2cli]], [[2clk]], [[2cll]], [[2clm]], [[2clo]], [[2clf]] - StTrpS α + β + inhibitor + PLP<br />
[[1fuy]] - StTrpS α + β (mutant) + inhibitor + PLP<br />
[[1fuy]] - StTrpS α + β (mutant) + inhibitor + PLP<br />
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==TrpS ternary complex with PLP and IGP derivatives==
+
''TrpS α+β ternary complex with PLP and IGP derivatives''
[[1a5b]], [[1kfb]] - StTrpS α (mutant) + β + IGP + PLP<br />
[[1a5b]], [[1kfb]] - StTrpS α (mutant) + β + IGP + PLP<br />
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[[2trs]], [[1beu]] - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + IGP analog
[[2trs]], [[1beu]] - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + IGP analog
-
 
+
''TrpS α+β ternary complex with PLP and G3P derivatives''
-
==TrpS ternary complex with PLP and G3P derivatives==
+
[[1wbj]] - StTrpS α + β + G3P + PLP<br />
[[1wbj]] - StTrpS α + β + G3P + PLP<br />
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[[1ubs]] - StTrpS α (mutant) + β (mutant) + serine + PLP<br />
[[1ubs]] - StTrpS α (mutant) + β (mutant) + serine + PLP<br />
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==TrpS quaternary complex==
+
''TrpS α+β quaternary complex''
[[1a5s]] - StTrpS α + β + serine + inhibitor + PLP<br />
[[1a5s]] - StTrpS α + β + serine + inhibitor + PLP<br />

Revision as of 08:36, 21 August 2014

Template:STRUCTURE 1wbj

Tryptophan synthase (TrpS) is an α2β2 tetramer participating in the biosynthesis of tryptophan. TrpS α subunit catalyzes the formation of indole and glyceraldehyde-3-phosphate (G3P) from indole-3-glycerol phosphate (IGP). The β subunit catalyzes in a pyridoxal-phosphate (PLP) dependent reaction the formation of tryptophan (Trp) from indole and serine. The diffusion of indole from the α to the β subunit is facilitated via a hydrophobic channel connecting the subunits. TrpS is not found in animals hence it is tested as a possible drug target for tubertculosis, ocular and genital infections, cryptosporidiosis and as herbicide.

Contents

3D structures of tryptophan synthase

Updated on 21-August-2014

TrpS α subunit

3vnd - TrpS α subunit – Shewanella frigidimarina
3tha - TrpS α subunit – Campylobacter jejuni
3nav - TrpS α subunit – Vibrio cholerae
1geq - PfTrpS α subunit - Pyrococcus furiosus
2dzp, 2dzs, 2dzt, 2dzu, 2dzv, 2dzw, 2dzx, 2e09 - PfTrpS α subunit (mutant)
1rd5 - TrpS α subunit – corn
1ujp - TtTrpS α subunit
1v7y, 1wq5, 1xc4 - EcTrpS α subunit
1xcf - EcTrpS α subunit (mutant)
2ekc - TrpS α subunit – Aquifex aeolicus

TrpS α binary complex

1wxj - TtTrpS α subunit + indole propanol phosphate

TrpS β subunit

1x1q - TtTrpS β subunit – Thermus thermophilus
2dh6 - EcTrpS β subunit]] - Escherichia coli
2o2e, 2o2j - TrpS β subunit – Mycobacterium tuberculosis
1v8z - PfTrpS β subunit
4neg - TrpS β subunit – Bacillus anthracis

TrpS β binary complex

2dh5 - EcTrpS β subunit + PLP

TrpS α+β subunits

1wdw - PfTrpS α + β subunits

TrpS α+β binary complex

1ttp, 1ttq, 1bks, 2wsy, 1kfk - StTrpS α + β + PLP – Salmonella typhimurium
1a5a, 1k8x - StTrpS α (mutant) + β + PLP
1k7x, 2j9z - StTrpS α + β (mutant) + PLP
2tys - StTrpS α (mutant) + β (mutant) + Trp derivative
1kfe - StTrpS α (mutant) + β + pyridoxal-serine-monophsphate
1kfj - StTrpS α + β + pyridoxal-serine-monophsphate
2j9y - StTrpS α + β (mutant) + enoic acid derivative
3pr2 - StTrpS α + β + inhibitor
4hn4, 4hpj, 4hpx, 4ht3, 4kkx - TrpS α + β + inhibitor – Salmonella enterica

TrpS α+β ternary complex with PLP and inhibitor

1a50, 1cw2, 1c9d, 1cx9, 1c8v, 1c29, 2cle, 2clh, 2cli, 2clk, 2cll, 2clm, 2clo, 2clf - StTrpS α + β + inhibitor + PLP
1fuy - StTrpS α + β (mutant) + inhibitor + PLP

TrpS α+β ternary complex with PLP and IGP derivatives

1a5b, 1kfb - StTrpS α (mutant) + β + IGP + PLP
1k8z - StTrpS α + β (mutant) + IGP derivative + PLP
1kfc - StTrpS α (mutant) + β + IGP derivative + PLP
1k3u, 1k7e, 1k7f - StTrpS α + β + IGP derivative + PLP
1qoq, 2rh9, 2rhg - StTrpS α + β + IGP + PLP
1qop - StTrpS α + β + IGP analog + PLP
2trs, 1beu - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + IGP analog

TrpS α+β ternary complex with PLP and G3P derivatives

1wbj - StTrpS α + β + G3P + PLP
2j9x - StTrpS α + β + G3P + acrylic acid derivative
1k8y - StTrpS α + β (mutant) + G3P derivative + PLP
1tjp - StTrpS α + β + G3P derivative + PLP
2tsy - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + G3P

1ubs - StTrpS α (mutant) + β (mutant) + serine + PLP

TrpS α+β quaternary complex

1a5s - StTrpS α + β + serine + inhibitor + PLP
3cep - StTrpS α + β + G3P + indoline + PLP

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Amer Ali

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