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Tumor necrosis factor receptor

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== Function ==
== Function ==
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'''Tumor necrosis factor receptor''' (TNFR) or '''death receptor''' is a trimeric cytokine receptor which binds TNF. TNFR family contains several members and superfamily (TNFRSF) members. The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains. TNFRSF 6 is called '''Fas'''; TNFRSF 10B is called '''Dr5'''; TNFRSF 21 is called '''Dr6'''; TNFRSF 11A is called '''RANK'''; TNFRSF 18 is called '''GITRL'''.
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'''Tumor necrosis factor receptor''' (TNFR) or '''death receptor''' is a trimeric cytokine receptor which binds TNF. TNFR family contains several members and superfamily (TNFRSF) members. The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains. '''TNFRSF 6''' is called '''Fas'''; '''TNFRSF 10B''' is called '''Dr5'''; '''TNFRSF 21''' is called '''Dr6'''; '''TNFRSF 11A''' is called '''RANK'''; '''TNFRSF 18''' is called '''GITRL'''.
== Disease ==
== Disease ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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'''TNFR-1'''
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===TNFR-1===
[[1ncf]] – hTNFR-1 residues 12-172 (mutant) – human<br />
[[1ncf]] – hTNFR-1 residues 12-172 (mutant) – human<br />
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[[3ona]] – evTNFR SECRET domain + CX3CL1 <br />
[[3ona]] – evTNFR SECRET domain + CX3CL1 <br />
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'''TNFRSF-1B'''
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===TNFRSF-1B===
[[3alq]] – hTNFRSF-1B extracellular domain + TNF<br />
[[3alq]] – hTNFRSF-1B extracellular domain + TNF<br />
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'''TNFRSF-6 (Fas)'''
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===TNFRSF-6 (Fas)===
[[3thm]], [[3tje]] – hTNFRSF-6 extracellular domain + antibody<br />
[[3thm]], [[3tje]] – hTNFRSF-6 extracellular domain + antibody<br />
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[[3oq9]] – mTNFRSF-6 Fas DD domain + FADD - mouse<br />
[[3oq9]] – mTNFRSF-6 Fas DD domain + FADD - mouse<br />
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'''TNFRSF-6B'''
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===TNFRSF-6B===
[[3mhd]] – hTNFRSF-6B extracellular domain <br />
[[3mhd]] – hTNFRSF-6B extracellular domain <br />
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[[3k51]] – hTNFRSF-6B cysteine-rich domain + hTNFRSF-15 extracellular domain<br />
[[3k51]] – hTNFRSF-6B cysteine-rich domain + hTNFRSF-15 extracellular domain<br />
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'''TNFRSF-10B (Dr5)'''
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===TNFRSF-10B (Dr5)===
[[2h9g]], [[4od2]], [[1za3]] – hTNFRSF-10B extracellular domain + antibody<br />
[[2h9g]], [[4od2]], [[1za3]] – hTNFRSF-10B extracellular domain + antibody<br />
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[[1d4v]] – hTNFRSF-10B extracellular domain + TNF-related apoptosis inducing ligand<br />
[[1d4v]] – hTNFRSF-10B extracellular domain + TNF-related apoptosis inducing ligand<br />
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'''TNFRSF-11A (RANK)'''
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===TNFRSF-11A (RANK)===
[[3me4]] – mTNFRSF-11A extracellular domain <br />
[[3me4]] – mTNFRSF-11A extracellular domain <br />
[[4giq]], [[3qbq]], [[3me2]] – mTNFRSF-11A extracellular domain + RANKL <br />
[[4giq]], [[3qbq]], [[3me2]] – mTNFRSF-11A extracellular domain + RANKL <br />
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'''TNFRSF-12A'''
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===TNFRSF-12A===
[[2rpj]] – hTNFRSF-12A cysteine-rich domain – NMR <br />
[[2rpj]] – hTNFRSF-12A cysteine-rich domain – NMR <br />
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'''TNFRSF-18 (GITRL)'''
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===TNFRSF-18 (GITRL)===
[[4db5]] – TNFRSF-18 – rabbit <br />
[[4db5]] – TNFRSF-18 – rabbit <br />
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[[2r30]], [[2r32]] – hTNFRSF-18 extracellular domain (mutant) <br />
[[2r30]], [[2r32]] – hTNFRSF-18 extracellular domain (mutant) <br />
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'''TNFRSF-21 (Dr6)'''
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===TNFRSF-21 (Dr6)===
[[3u3p]], [[3u3q]], [[3u3s]], [[3u3t]], [[3u3v]] – hTNFRSF-21 cysteine-rich domain<br />
[[3u3p]], [[3u3q]], [[3u3s]], [[3u3t]], [[3u3v]] – hTNFRSF-21 cysteine-rich domain<br />
[[2dbh]] – hTNFRSF-21 CARD-like domain - NMR<br />
[[2dbh]] – hTNFRSF-21 CARD-like domain - NMR<br />
[[3qo4]] – hTNFRSF-21 residues 42-218<br />
[[3qo4]] – hTNFRSF-21 residues 42-218<br />
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== References ==
== References ==

Revision as of 08:42, 21 August 2014

Structure of human TNFRSF-18 extracellular domain (PDB code 2q1m).

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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