Villin
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{{STRUCTURE_2k6n| right| PDB=2k6n | SCENE=Villin/Cv/1 |CAPTION=Human supervillin headpiece, [[2k6n]] }} | {{STRUCTURE_2k6n| right| PDB=2k6n | SCENE=Villin/Cv/1 |CAPTION=Human supervillin headpiece, [[2k6n]] }} | ||
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[[Villin]] (VIL) is an actin-binding protein. It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin<ref>PMID:10480879</ref>. '''Supervillin (SVIL)''' contains numerous gelsolin-like domains in its C-terminal and interacts with actin. '''Advillin (AVIL)''' is another actin-binding protein in the [[gelsolin]] superfamily which is expressed in the peripheral sensory neurons. '''Cytovillin (CVIL) or ezrin or villin-2''' serves as intermediate between plasma membrane and actin cytoskeleton. images on the left and right correspond to one representative villin structure, ''i.e.'' the human supervillin headpiece ([[2k6n]]). | [[Villin]] (VIL) is an actin-binding protein. It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin<ref>PMID:10480879</ref>. '''Supervillin (SVIL)''' contains numerous gelsolin-like domains in its C-terminal and interacts with actin. '''Advillin (AVIL)''' is another actin-binding protein in the [[gelsolin]] superfamily which is expressed in the peripheral sensory neurons. '''Cytovillin (CVIL) or ezrin or villin-2''' serves as intermediate between plasma membrane and actin cytoskeleton. images on the left and right correspond to one representative villin structure, ''i.e.'' the human supervillin headpiece ([[2k6n]]). | ||
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== 3D Structures of Villin == | == 3D Structures of Villin == | ||
Revision as of 09:33, 21 August 2014
Villin (VIL) is an actin-binding protein. It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin[1]. Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin. Advillin (AVIL) is another actin-binding protein in the gelsolin superfamily which is expressed in the peripheral sensory neurons. Cytovillin (CVIL) or ezrin or villin-2 serves as intermediate between plasma membrane and actin cytoskeleton. images on the left and right correspond to one representative villin structure, i.e. the human supervillin headpiece (2k6n).
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3D Structures of Villin
Updated on 21-August-2014
Supervillin
2k6m, 2k6n – hSVIL headpiece– human – NMR
Villin
3fg7 – hVIL gelsolin domains 4-6
2llf - hVIL gelsolin-like domain 6 - NMR
1unc – hVIL headpiece
3iur - hVIL headpiece H2H3 helices+prolyl endopeptidase – Aeromonas punctata
2rjw, 2rjx, 2rjv, 2rjy, 1yu7, 1yu8 – cVIL headpiece (mutant) – chicken
1yu5, 1qqv - cVIL headpiece
3myc, 3mye, 3nkj, 3mya, 3tjw, 3trv, 3trw, 3try - cVIL headpiece (mutant)
1vii, 2vik, 2vil - cVIL headpiece - NMR
2ppz, 2jm0 - VIL headpiece (mutant) – synthetic – NMR
2f4k, 1wy3, 1wy4, 1yrf, 1yri - VIL fragment (mutant) – synthetic
Advillin
1und – hAVIL headpiece
Cytovillin
1ni2 – hCVIL N terminal
References
- ↑ Friederich E, Vancompernolle K, Louvard D, Vandekerckhove J. Villin function in the organization of the actin cytoskeleton. Correlation of in vivo effects to its biochemical activities in vitro. J Biol Chem. 1999 Sep 17;274(38):26751-60. PMID:10480879
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