RmlC is an enzyme of the dTPD-rhamnose pathway. Deoxy-thymidine diphosphate (dTDP)-L-rhamnose is the precursor of L-rhamnose. L-rhamnose is a sugar component of microbial cell wall and is absent in human.
Function
Disease
Relevance
Inhibitors of RmlC can serve as potential antimicrobial drugs.
Structural highlights
3D structures of RmlC
Updated on 21-August-2014
1pm7, 1upi – MtRmlC – Mycobacterium tuberculosis
2ixj, 1rtv – PaRmlC – Pseudomonas aeruginosa
1nxm – SsRmlC – Streptococcus suis
1ep0 – MetRmlC – Methanothermobacter thermautotrophicus
1dzr – StRmlC – Salmonella typhimurium
RmlC complexes
2ixc – MtRmlC + dTDP rhamnose
2ixh – PaRmlC + dTDP rhamnose
2ixl – SsRmlC + dTDP rhamnose
2ixk – PaRmlC + dTDP-keto rhamnose
1nyw – SsRmlC + dTDP glucose
1nzc – SsRmlC + dTDP xylose
1epz – MetRmlC + TDP
3ryk – RmlC + TDP + pyrophosphate – Bacillus anthracis
1dzt – StRmlC + acetylthymidine diphosphate
References
