Aldehyde dehydrogenase
From Proteopedia
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[[4i3v]], [[4i3w]] – SmALDH + aldehyde derivative + NAD<br /> | [[4i3v]], [[4i3w]] – SmALDH + aldehyde derivative + NAD<br /> | ||
[[4i3x]] – SmALDH + phosphonoacete + NAD<br /> | [[4i3x]] – SmALDH + phosphonoacete + NAD<br /> | ||
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| - | ===NAD-dependent glyceraldehyde-3-phosphate dehydrogenase=== | ||
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| - | [[1vsu]] – CpGAPDH – ''Cryptosporidium parvum''<BR /> | ||
| - | [[1ywg]] – PfGAPDH – ''Plasmodium falciparum''<BR /> | ||
| - | [[3cmc]] - GAPDH – ''Bacillus stearothermophilus''<BR /> | ||
| - | [[2ep7]] – GAPDH – ''Aquifex aeolicus''<BR /> | ||
| - | [[2i5p]] – GAPDH – ''Kluyveromyces marxianus''<BR /> | ||
| - | [[1obf]] – GAPDH – ''Achromobacter xylosoxidans''<BR /> | ||
| - | [[1crw]] – PvGAPDH – ''Palinurus versicolor''<BR /> | ||
| - | [[1b7g]] – GAPDH – ''Sulfolobus solfataricus''<BR /> | ||
| - | [[2gd1]] – GsGAPDH – ''Geobacillus stearothermophilus''<BR /> | ||
| - | [[3e6a]] – OsGAPDH – ''Oryza sativa''<BR /> | ||
| - | [[4gpd]], [[1gpd]] – GAPDH – lobster<BR /> | ||
| - | [[3l6o]], [[3lc7]] – SaGAPDH<BR /> | ||
| - | [[1dc3]], [[1dc5]], [[1s7c]] – EcGAPDH - ''Escherichia coli'' | ||
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| - | ''GAPDH binary complex'' | ||
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| - | [[1k3t]] - TcGAPDH + inhibitor<BR /> | ||
| - | [[3hja]] - GAPDH + NAD – ''Borellia burgdorferi''<BR /> | ||
| - | [[1vsv]], [[3cps]] - CpGAPDH + NAD<BR /> | ||
| - | [[2vyn]], [[2vyv]] - rGAPDH residues 102-432 + EcGAPDH + NAD<BR /> | ||
| - | [[2b4r]], [[2b4t]] – PfGAPDH (mutant) + NAD<BR /> | ||
| - | [[1j0x]] – GAPDH + NAD – rabbit<BR /> | ||
| - | [[1ihx]] – PvGAPDH + NAD<BR /> | ||
| - | [[1dss]], [[1szj]] - PvGAPDH NAD-binding and catalytic domains+ NAD<BR /> | ||
| - | [[1ihy]] – PvGAPDH + ADP-ribose<BR /> | ||
| - | [[1gyq]], [[1gyp]] - LmGAPDH + NAD derivative – ''Leishmania mexicana''<BR /> | ||
| - | [[1i32]], [[1i33]] – LmGAPDH + inhibitor<BR /> | ||
| - | [[1a7k]] – LmGAPDH + NAD<BR /> | ||
| - | [[1cer]], [[2g82]] - GAPDH + NAD – ''Thermus aquaticus''<BR /> | ||
| - | [[1gd1]] - GsGAPDH + NAD<BR /> | ||
| - | [[1npt]], [[1nq5]], [[1dbv]], [[2dbv]], [[3dbv]], [[4dbv]] - GsGAPDH (mutant) + NAD<BR /> | ||
| - | [[3e5r]] – OsGAPDH + NAD<BR /> | ||
| - | [[3k73]], [[3lvf]] – SaGAPDH + NAD<BR /> | ||
| - | [[3lc2]] - SaGAPDH + G3P<BR /> | ||
| - | [[3k9q]], [[3ksd]], [[3lc1]], [[3hq4]] - SaGAPDH (mutant) + NAD<BR /> | ||
| - | [[3gpd]], [[1u8f]], [[1znq]] – hGAPDH + NAD<BR /> | ||
| - | [[1gad]], [[1dc6]] - EcGAPDH + NAD<BR /> | ||
| - | [[1gae]] - EcGAPDH (mutant) + NAD<BR /> | ||
| - | [[1dc4]] – EcGAPDH + G3P<BR /> | ||
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| - | ''GAPDH ternary complex'' | ||
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| - | [[3id5]], [[3dmt]], [[1ml3]] – TcGAPDH + NAD + inhibitor – ''Trypanosoma cruzi''<BR /> | ||
| - | [[1qxs]] - TcGAPDH + NAD + G3P analog<BR /> | ||
| - | [[3cif]] - CpGAPDH + NAD + G3P<BR /> | ||
| - | [[1nqa]], [[1nqo]] - GsGAPDH (mutant) + NAD + G3P<BR /> | ||
| - | [[3ksz]], [[3kv3]], [[3l4s]] - SaGAPDH (mutant) + NAD + G3P<BR /> | ||
===NADP-dependent ALDH=== | ===NADP-dependent ALDH=== | ||
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[[2vro]] – BxALDH + NADP + alcohol | [[2vro]] – BxALDH + NADP + alcohol | ||
| - | ===NADP-dependent glyceraldehyde-3-phosphate dehydrogenase=== | ||
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| - | [[1euh]] - SmGAPDH – ''Streptococcus mutans''<BR /> | ||
| - | [[1qi6]] - SmGAPDH (mutant) | ||
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| - | ''GAPDH binary complex'' | ||
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| - | [[2euh]] - SmGAPDH + NADP<BR /> | ||
| - | [[2yyy]] – MjGAPDH + NADP <BR /> | ||
| - | [[2pkq]] - spGAPDH subunit A, B + NADP <BR /> | ||
| - | [[2pkr]], [[1rm4]], [[1jn0]] - spGAPDH subunit A + NADP<BR /> | ||
| - | [[1rm3]], [[1rm5]] - spGAPDH subunit A (mutant) + NADP<BR /> | ||
| - | [[2czc]] – GAPDH + NADP – ''Pyrococcus horikoshii'' | ||
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| - | ''GAPDH ternary complex'' | ||
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| - | [[2esd]], [[1qi1]] – SmGAPDH (mutant) + NADP + G3P<BR /> | ||
[[3k9d]] – ALDH – ''Listeria monocytogenes'' | [[3k9d]] – ALDH – ''Listeria monocytogenes'' | ||
Revision as of 09:26, 24 August 2014
Aldehyde dehydrogenase (ALDH) converts aldehydes to carboxylic acids while reducing NAD+ to NADH. In mammals there are 3 classes of ALDH and each contain constitutive and inducible forms. Class 1 is cytosolic; class 2 mitochondrial; class 3 found in tumors, stomach and cornea. ALDH family 7 member A1 is known as antiquitin and functions in the detoxification of aldehydes. Glyceraldehyde-3-phophate (G3P)-ALDH is called GAPDH.
Contents |
3D Structures of Aldehyde dehydrogenase
Updated on 24-August-2014
ALDH class 1
3fx4 – ALDH1 + NADP + inhibitor – pig
1bxs – ALDH1 - sheep
1o9j – ALDH1 + NAD – Elephant shrew
3rhj, 3rhl, 3rho, 3rhp, 3rhq, 3rhr – rALDH1 C- terminal (mutant) + NADP – rat
3rhm - rALDH1 C- terminal
1hso – hALDH1 α subunit + Zn + NAD
1ht0 – hALDH1 γ subunit (mutant) + Zn + NAD
ALDH class 2
3n80, 1o05 – hALDH2 residues 18-517- human
3n81, 2onn, 2ono, 1zum – hALDH2 residues 18-517 (mutant)
1ag8 – bALDH NAD binding domain - bovine
Binary complex
3inj, 3inl - hALDH2 residues 18-517 + agonist
2vle - hALDH2 residues 24-517 + daidzin
1nzx, 1nzz, 1o00, 1o02, 1cw3 - hALDH2 residues 18-517 + NAD
3n82, 3n83, 2onm, 2onp, 1nzw, 1o04 – hALDH2 residues 18-517 (mutant) + NADH
3sz9 - hALDH2 residues 18-517 + inhibitor
1a4z – bALDH2 NAD-binding domain + NAD
Ternary complex
1o01 - hALDH2 residues 18-517 + NADH + aldehyde
4fqf - hALDH2 residues 18-517 + NAD + NO2
4fr8 - hALDH2 residues 18-517 (mutant) + NAD + ADP + nitroglycerin
ALDH class 3
1ad3 – rALDH
3sza - hALDH
3qj5, 3szb – hALDH + inhibitor
4h80 - hALDH (mutant) + inhibitor
NAD-dependent ALDH
2w8n, 2w8o, 2w8r – Succinate–semi-hALDH family 5
2w8p - Succinate–semi-hALDH family 5 (mutant)
3r31 – Betaine-ALDH – Agrobacterium tumefaciens
3ed6, 4mpb, 4nu9 - Betaine-SaALDH – Staphylococcus aureus
1a4s - Betaine-cALDH - cod
3llg, 3tz6, 3vos – Aspartate-semi-MtALDH
2cq8 - Formyltetrahydrofolate-hALDH PP-binding domain - NMR
2nac – Formate-PsALDH
3i44 – ALDH – Bartonella henselae
3ek1 – ALDH – Brucella melitensis
3ros – ALDH – Lactobacillus acidophilus
3r64 – ALDH – Corynebacterium glutamicum
3rhe – Benzaldehyde-ALDH – Legionella pneumophila
3u4j, 4i3t – SmALDH – Sinorhizobium meliloti
Binary complexes
2w8q - Succinate–semi-hALDH family 5 + succinic acid
3fg0, 4mpy, 4nea - Betaine-SaALDH + NAD
4ni4 - Betaine-SaALDH (mutant) + NAD
1bpw - Betaine-cALDH + NAD
2j6l – Aminoadipate-semi-hALDH family 7 + NAD
2cfi - Formyltetrahydrofolate-hALDH hydrolase domain + formyltetrahydropterin
2nad - Formate-PsALDH + NAD – Pseudomonas
1bi9 – Retinal-rALDH2 + NAD
3l4p, 1sij – ALDH + AsO3 – Desulfovibrio gigas
4a0m – spALDH + NAD – spinach
3iwk – amino-ALDH + NAD – pea
3ju8 - Succinylglutamic–semi-PaALDH + NAD – Pseudomonas aeruginosa
4c3s - ALDH + NAD – Clostridium phytofermentans
4i3u – SmALDH + phosphonoacetaldehyde
Ternary complexes
2gsd – Formate-ALDH + NAD + azide – Moraxella
1nvm – Acetaldehyde-PsALDH + 4-hydroxy-oxovalerate aldolase + NAD
1llu - PaALDH + NAD + alcohol
4i3v, 4i3w – SmALDH + aldehyde derivative + NAD
4i3x – SmALDH + phosphonoacete + NAD
NADP-dependent ALDH
3k2w - Betaine-ALDH – Pseudoalteromonas atlantica
2hg2, 2opx – Lactaldehyde-EcALDH
2o2p – Formyltetrahydrofolate-rALDH C-terminal
2y51, 2y52, 2y53, 2y5d – BxALDH (mutant) – Burkholderia xenovorans
3ifg, 3ifh - Succinate–semi-ALDH – Burkholderia pseudomallei
3rh9 - Succinate–semi-ALDH – Marinobacter aquaeolei
3uw3 - aspartate–semi-ALDH – Burkholderia thailandensis
3v4c - SmALDH
Binary complexes
2wox, 2wme, 2xdr, 3zqa - Betaine-PaALDH + NADP
3lv1 – Benzaldehyde-PpALDH3 + NADP – Pseudomonas putida
2ilu - Lactaldehyde-EcALDH + NADP
3rhd - Lactaldehyde-MjALDH + NADP - Methanocaldococcus jannaschii
2o2q, 2o2r - Formyltetrahydrofolate-rALDH C-terminal + NADP
3b4w - MtALDH + NADP – Mycobacterium tuberculosis
1eyy, 1ez0 – ALDH + NADP – Vibrio harveyi
3jz4 - Succinate–semi-EcALDH + NADP
3hsk - aspartate–semi-ALDH + NADP – Candida albicans
4h73 - ALDH + NADP – Pyrobaculum
Ternary complexes
3lns - Benzaldehyde-PpALDH3 + NADP + benzoate
2imp - Lactaldehyde-EcALDH + NADH + lactate
2vro – BxALDH + NADP + alcohol
3k9d – ALDH – Listeria monocytogenes
Antiquitin
2jg7 – Antiquitin – Acanthopagrus schlegeli
3my7 – ALDH – Vibrio parahaemolyticus
