Cluster of Differentiation CD38

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[[Image:3gc6a.jpg|left|200px|thumb|Crystal Structure of bovine Cluster of Differentiation 38 (CD38) [[3gc6]]]]
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{{STRUCTURE_3gc6| PDB=3gc6 | SIZE=400| SCENE=Cluster_of_Differentiation_38/Cv/1 |right|CAPTION=Cluster of Differentiation 38 (CD38) complex with sulfate [[3gc6]] }}
{{STRUCTURE_3gc6| PDB=3gc6 | SIZE=400| SCENE=Cluster_of_Differentiation_38/Cv/1 |right|CAPTION=Cluster of Differentiation 38 (CD38) complex with sulfate [[3gc6]] }}
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[[Cluster of Differentiation 38]] (CD38), known also as ''ADP-ribosyl cyclase 1'' (ADPRC1), catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR). It is found on the surface of immune cells. It also functions in cell adhesion, signal transduction and Ca++ signaling.
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[[Cluster of Differentiation 38]] (CD38), known also as ''ADP-ribosyl cyclase 1'' (ADPRC1), catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR). It is found on the surface of immune cells. It also functions in cell adhesion, signal transduction and Ca++ signaling. The images at the left and at the right correspond to one representative CD38, ''i.e.'' the crystal structure of bovine Cluster of Differentiation 38 ([[3gc6]]).
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Revision as of 05:54, 26 August 2014

Template:STRUCTURE 3gc6

Cluster of Differentiation 38 (CD38), known also as ADP-ribosyl cyclase 1 (ADPRC1), catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR). It is found on the surface of immune cells. It also functions in cell adhesion, signal transduction and Ca++ signaling.

Contents

3D Structures of Cluster of Differentiation 38

Updated on 26-August-2014

CD38

3gc6 – bCD38 - bovine
3gh3, 3ghh – bCD38 residues 32-278
2eg9 - CD38 enzymatic domain (mutant) – mouse
2ef1 - hCD38 enzymatic domain – human
1yh3 - hCD38 enzymatic domain (mutant)
1zvm - hCD38 (mutant)

CD38+ligand

3i9m, 3i9n – hCD38 enzymatic domain+ADPR analog
3f6y – hCD38 enzymatic domain+Ca++
3dzf - hCD38 enzymatic domain+intermediate
3dzg - hCD38 enzymatic domain (mutant)+intermediate/nicotinamide complex
3dzh - hCD38 enzymatic domain (mutant)+GTP
3dzi - hCD38 enzymatic domain (mutant)+intermediate/GTP complex
3dzj, 3dzk - hCD38 enzymatic domain (mutant)+NMN complex
2pgj, 2pgl - hCD38 enzymatic domain (mutant)+substrate analog
2o3t - hCD38 enzymatic domain (mutant)+cGDPR
3u4h, 3u4i - hCD38 enzymatic domain (mutant)+cIDPR
2o3u - hCD38 enzymatic domain (mutant)+NGD
2o3q, 2o3r, 2o3s - hCD38 enzymatic domain (mutant)+cADPR
4f45 - hCD38 enzymatic domain (mutant)+ NAADP
4f46 - hCD38 enzymatic domain (mutant)+ NAADP + ADPRP
2i65 – hCD38+NAD
2i66 - hCD38 (mutant)+GDP intermediate
2i67 - hCD38 (mutant)+ADPR
2hct - hCD38 enzymatic domain (mutant)+NMN
3ofs - hCD38 enzymatic domain (mutant)+ ARA-2 F-ADPR
3raj - hCD38 enzymatic domain (mutant)+ FAB
3rok, 3rom - hCD38 (mutant) + arabinitol derivative
3roq - hCD38 (mutant) + hydrofuran derivative
3rop - hCD38 (mutant) + arabinitol derivative + nicotinamide
1isf – hCD38 (mutant)

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

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