CD47
From Proteopedia
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{{STRUCTURE_2jjs| PDB=2jjs | SIZE=400| SCENE= |right|CAPTION=Glycosylated human CD47 residues 19-136 (mutant) (pink and yellow) complex with SIRP α (grey and green) and I- ions [[2jjs]] }} | {{STRUCTURE_2jjs| PDB=2jjs | SIZE=400| SCENE= |right|CAPTION=Glycosylated human CD47 residues 19-136 (mutant) (pink and yellow) complex with SIRP α (grey and green) and I- ions [[2jjs]] }} | ||
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'''CD47 (Cluster of Differentiation 47)''' is a protein which is expressed by cancer cells to avoid detection by the immune system. CD47 consists of an extracellular N-terminal immunoglobulin-like domain, a transmembrane domain and a C-terminal intracellular domain. CD47 is a receptor for thrombospondin-1 and their association influences cell migration and adhesion. CD47 is a receptor for SIRP1 and their association influences inhibition of phagocytosis. CD47 is a receptor for several integrins and their association influences cell migration and adhesion. CD47 leads to cell death via apoptosis. Antibodies against CD47 were found to bring effective cure against cancer in mice in a variety of cancers tested. | '''CD47 (Cluster of Differentiation 47)''' is a protein which is expressed by cancer cells to avoid detection by the immune system. CD47 consists of an extracellular N-terminal immunoglobulin-like domain, a transmembrane domain and a C-terminal intracellular domain. CD47 is a receptor for thrombospondin-1 and their association influences cell migration and adhesion. CD47 is a receptor for SIRP1 and their association influences inhibition of phagocytosis. CD47 is a receptor for several integrins and their association influences cell migration and adhesion. CD47 leads to cell death via apoptosis. Antibodies against CD47 were found to bring effective cure against cancer in mice in a variety of cancers tested. | ||
Revision as of 05:57, 26 August 2014
CD47 (Cluster of Differentiation 47) is a protein which is expressed by cancer cells to avoid detection by the immune system. CD47 consists of an extracellular N-terminal immunoglobulin-like domain, a transmembrane domain and a C-terminal intracellular domain. CD47 is a receptor for thrombospondin-1 and their association influences cell migration and adhesion. CD47 is a receptor for SIRP1 and their association influences inhibition of phagocytosis. CD47 is a receptor for several integrins and their association influences cell migration and adhesion. CD47 leads to cell death via apoptosis. Antibodies against CD47 were found to bring effective cure against cancer in mice in a variety of cancers tested.
3D Structures of CD47
Updated on 26-August-2014
2jjs, 2jjt, 4kjy – hCD47 extracellular domain (mutant) + SIRP α
2vsc – hCD47 extracellular domain (mutant)
4cmm - hCD47 extracellular domain (mutant) + tyrosine-protein phosphatase non-receptor type substrate
