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Cocaine esterase
From Proteopedia
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[[1l7r]], [[3pui]] - RhCocE (mutant) | [[1l7r]], [[3pui]] - RhCocE (mutant) | ||
| - | + | ===Cocaine esterase binary complex=== | |
[[1ju3]] – RhCocE + transition state inhibitor <br /> | [[1ju3]] – RhCocE + transition state inhibitor <br /> | ||
Revision as of 08:16, 26 August 2014
Cocaine esterase (CocE) catalyzes the hydrolysis of the benzoyl ester of cocaine to ecgonine methyl ester and benzoic acid. CocE contains 3 domains. Domain 1 contains the catalytic triad: Ser, Asp and His typical of the hydrolase family. Domains 2 and 3 are involved in substrate recognition. CocE is produced by bacteria which thrive in soil of cocaine-producing plants. These bacteria use cocaine as their sole source of carbon and nitrogen. CocE is being investigated as a possible therapeutic agent for treatment of cocaine abuse.
3D structures of cocaine esterase
Updated on 26-August-2014
3i2j, 3puh - RhCocE – Rhodococcus
1l7r, 3pui - RhCocE (mutant)
Cocaine esterase binary complex
1ju3 – RhCocE + transition state inhibitor
1ju4 – RhCocE + benzoic acid
1l7q - RhCocE (mutant) + benzoic acid
3ida, 3i2f, 3i2g, 3i2h, 3i2i - RhCocE (mutant) + DTT derivative
3i2k - RhCocE + DTT derivative
