4mzv
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of extracellular part of human EpCAM== |
| - | + | <StructureSection load='4mzv' size='340' side='right' caption='[[4mzv]], [[Resolution|resolution]] 1.86Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4mzv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MZV FirstGlance]. <br> | |
| - | + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene><br> | |
| - | + | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr> | |
| - | + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mzv RCSB], [http://www.ebi.ac.uk/pdbsum/4mzv PDBsum]</span></td></tr> | |
| + | <table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/EPCAM_HUMAN EPCAM_HUMAN]] Intestinal epithelial dysplasia;Hereditary nonpolyposis colon cancer. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:18572020</ref> The disease is caused by mutations affecting the gene represented in this entry. HNPCC8 results from heterozygous deletion of 3-prime exons of EPCAM and intergenic regions directly upstream of MSH2, resulting in transcriptional read-through and epigenetic silencing of MSH2 in tissues expressing EPCAM.<ref>PMID:19098912</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/EPCAM_HUMAN EPCAM_HUMAN]] May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.<ref>PMID:15195135</ref> <ref>PMID:15922867</ref> <ref>PMID:20064925</ref> <ref>PMID:19785009</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Djinovic-Carugo, K.]] | ||
| + | [[Category: Guncar, G.]] | ||
| + | [[Category: Lenarcic, B.]] | ||
| + | [[Category: Pavsic, M.]] | ||
| + | [[Category: Cell adhesion]] | ||
| + | [[Category: Dimer]] | ||
| + | [[Category: Ectodomain]] | ||
| + | [[Category: Extracellular space]] | ||
Revision as of 08:51, 27 August 2014
Crystal structure of extracellular part of human EpCAM
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