1dzi

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[[Image:1dzi.gif|left|200px]]<br /><applet load="1dzi" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1dzi.gif|left|200px]]
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caption="1dzi, resolution 2.1&Aring;" />
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'''INTEGRIN ALPHA2 I DOMAIN / COLLAGEN COMPLEX'''<br />
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{{Structure
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|PDB= 1dzi |SIZE=350|CAPTION= <scene name='initialview01'>1dzi</scene>, resolution 2.1&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene> and <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''INTEGRIN ALPHA2 I DOMAIN / COLLAGEN COMPLEX'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1DZI is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CO:'>CO</scene> and <scene name='pdbligand=NH2:'>NH2</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZI OCA].
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1DZI is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZI OCA].
==Reference==
==Reference==
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Structural basis of collagen recognition by integrin alpha2beta1., Emsley J, Knight CG, Farndale RW, Barnes MJ, Liddington RC, Cell. 2000 Mar 31;101(1):47-56. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10778855 10778855]
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Structural basis of collagen recognition by integrin alpha2beta1., Emsley J, Knight CG, Farndale RW, Barnes MJ, Liddington RC, Cell. 2000 Mar 31;101(1):47-56. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10778855 10778855]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: integrin]]
[[Category: integrin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:22:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:47:02 2008''

Revision as of 08:47, 20 March 2008

Image:1dzi.gif


PDB ID 1dzi

Drag the structure with the mouse to rotate
, resolution 2.1Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



INTEGRIN ALPHA2 I DOMAIN / COLLAGEN COMPLEX


Contents

Overview

We have determined the crystal structure of a complex between the I domain of integrin alpha2beta1 and a triple helical collagen peptide containing a critical GFOGER motif. Three loops on the upper surface of the I domain that coordinate a metal ion also engage the collagen, with a collagen glutamate completing the coordination sphere of the metal. Comparison with the unliganded I domain reveals a change in metal coordination linked to a reorganization of the upper surface that together create a complementary surface for binding collagen. Conformational changes propagate from the upper surface to the opposite pole of the domain, suggesting both a basis for affinity regulation and a pathway for signal transduction. The structural features observed here may represent a general mechanism for integrin-ligand recognition.

Disease

Known diseases associated with this structure: Glycoprotein Ia deficiency (1) OMIM:[192974], Neonatal alloimmune thrombocytopenia OMIM:[192974]

About this Structure

1DZI is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of collagen recognition by integrin alpha2beta1., Emsley J, Knight CG, Farndale RW, Barnes MJ, Liddington RC, Cell. 2000 Mar 31;101(1):47-56. PMID:10778855

Page seeded by OCA on Thu Mar 20 10:47:02 2008

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