Mitogen-activated protein kinase kinase

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[[Mitogen-activated protein kinase kinase]] (MAP2K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP2K is part of the MAPK cascade which consists also of [[Mitogen-activated protein kinase|MAPK]] and [[Mitogen-activated protein kinase kinase kinase|MAP3K]] which are activated by phosphorylation. '''MAP2K''' activates [[Mitogen-activated protein kinase|MAPK]]. The images on the left and right correspond to one representative MAP2K structure, ''i.e.'' the human MAP2K1 ([[3e8n]]).
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[[Mitogen-activated protein kinase kinase]] (MAP2K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP2K is part of the MAPK cascade which consists also of [[Mitogen-activated protein kinase|MAPK]] and [[Mitogen-activated protein kinase kinase kinase|MAP3K]] which are activated by phosphorylation. '''MAP2K''' activates [[Mitogen-activated protein kinase|MAPK]].

Revision as of 06:55, 2 September 2014

Image:3e8n.png
Crystal Structure of the Mitogen-activated protein kinase kinase, 3e8n

Template:STRUCTURE 1sko
















Mitogen-activated protein kinase kinase (MAP2K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP2K is part of the MAPK cascade which consists also of MAPK and MAP3K which are activated by phosphorylation. MAP2K activates MAPK.







Contents

3D Structures of Mitogen-activated protein kinase kinase

Updated on 02-September-2014

MAP2K1

3mbl, 3e8n, 3dy7, 3eqb, 2p55, 4ark – hMAP2K1 kinase domain +MgADP+ligand - human
3eqc – hMAP2K1 kinase domain+ATP-Gs+Mg2P
3eqd - hMAP2K1 kinase domain (mutant)+ATP-Gs+Mg2P
3eqf - hMAP2K1 kinase domain (mutant)+inhibitor+Mg2P
3eqg, 3eqi - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+Pd
3eqh - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+inhibitor
3orn, 4lmn, 3wig - hMAP2K1 kinase domain +MgAMP-PNP +inhibitor
3sls – hMAP2K1 kinase domain (mutant) + Mg + AMPPNP + inhibitor
4an2, 4an3, 4an9, 4anb – hMAP2K1 kinase domain (mutant) + Mg + ACP + inhibitor
3zls, 3zlw, 3zlx, 3zly, 3zm4 – hMAP2K1 kinase domain + inhibitor
3os3, 3pp1, 3v01, 3v04, 3vvh - hMAP2K1 kinase domain + MgATP +inhibitor
3eqi - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+Pd
3dv3 - hMAP2K1 residues 62-382+inhibitor
1s9j – hMAP2K1 +MgATP+ligand
3w8q – hMAP2K1 + ATP-γS
1sko - hMAP2K1+P14
3cpt - hMAP2K1+P14 (mutant)
2y4i – MAP2K1 + kinase suppressor of RAS 2 - rabbit
1vet, 1veu - mMAP2K1+P14 - mouse
4mne – hMAP2K1 + Mg + ATP-γS + proto-oncogene B-raf

MAP2K2

1s9i – hMAP2K2 +MgATP+ligand
1jky - hMAP2K2 + Anthrax lethal factor

MAP2K3

2o2v – hMAP2K3+ hMAP3K5

MAP2K4

3aln - hMAP2K4 kinase domain +AMPPNP
3alo - hMAP2K4 kinase domain + P38 peptide

MAP2K5

1wi0 - mMAP2K5 PB1 domain – NMR
1p38 – hMAP2K5+hMAP2KK2

MAP2K6

3an0 - hMAP2K6
3enm – hMAP2K6 (mutant)
3fme – hMAP2K6 kinase domain (mutant)

MAP2K7

2dyl – hMAP2K7 kinase domain (mutant)

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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