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1e0r
From Proteopedia
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| - | [[Image:1e0r.jpg|left|200px]] | + | [[Image:1e0r.jpg|left|200px]] |
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| - | '''BETA-APICAL DOMAIN OF THERMOSOME''' | + | {{Structure |
| + | |PDB= 1e0r |SIZE=350|CAPTION= <scene name='initialview01'>1e0r</scene>, resolution 2.8Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''BETA-APICAL DOMAIN OF THERMOSOME''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1E0R is a [ | + | 1E0R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E0R OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the beta-apical domain of the thermosome reveals structural plasticity in the protrusion region., Bosch G, Baumeister W, Essen LO, J Mol Biol. 2000 Aug 4;301(1):19-25. PMID:[http:// | + | Crystal structure of the beta-apical domain of the thermosome reveals structural plasticity in the protrusion region., Bosch G, Baumeister W, Essen LO, J Mol Biol. 2000 Aug 4;301(1):19-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10926489 10926489] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Thermoplasma acidophilum]] | [[Category: Thermoplasma acidophilum]] | ||
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[[Category: thermosome]] | [[Category: thermosome]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:47:38 2008'' |
Revision as of 08:47, 20 March 2008
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| , resolution 2.8Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
BETA-APICAL DOMAIN OF THERMOSOME
Overview
The crystal structure of the beta-apical domain of the thermosome, an archaeal group II chaperonin from Thermoplasma acidophilum, has been determined at 2.8 A resolution. The structure shows an invariant globular core from which a 25 A long protrusion emanates, composed of an elongated alpha-helix (H10) and a long extended stretch consisting of residues GluB245-ThrB253. A comparison with previous apical domain structures reveals a large segmental displacement of the protruding part of helix H10 via the hinge GluB276-ValB278. The region comprising residues GluB245-ThrB253 adopts an extended beta-like conformation rather than the alpha-helix seen in the alpha-apical domain. Consequently, it appears that the protrusions of the apical domains from group II chaperonins might assume a variety of context-dependent conformations during an open, substrate-accepting state of the chaperonin. Sequence variations in the protrusion regions that are found in the eukaryotic TRiC/CCT subunits may provide different structural propensities and hence serve different roles in substrate recognition.
About this Structure
1E0R is a Single protein structure of sequence from Thermoplasma acidophilum. Full crystallographic information is available from OCA.
Reference
Crystal structure of the beta-apical domain of the thermosome reveals structural plasticity in the protrusion region., Bosch G, Baumeister W, Essen LO, J Mol Biol. 2000 Aug 4;301(1):19-25. PMID:10926489
Page seeded by OCA on Thu Mar 20 10:47:38 2008
Categories: Single protein | Thermoplasma acidophilum | Baumeister, W. | Bosch, G. | Essen, L O. | Chaperonin | Groel | Hsp60 | Tcp1 | Thermosome
