1e0r

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[[Image:1e0r.jpg|left|200px]]<br /><applet load="1e0r" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1e0r.jpg|left|200px]]
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caption="1e0r, resolution 2.8&Aring;" />
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'''BETA-APICAL DOMAIN OF THERMOSOME'''<br />
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{{Structure
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|PDB= 1e0r |SIZE=350|CAPTION= <scene name='initialview01'>1e0r</scene>, resolution 2.8&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''BETA-APICAL DOMAIN OF THERMOSOME'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1E0R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E0R OCA].
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1E0R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E0R OCA].
==Reference==
==Reference==
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Crystal structure of the beta-apical domain of the thermosome reveals structural plasticity in the protrusion region., Bosch G, Baumeister W, Essen LO, J Mol Biol. 2000 Aug 4;301(1):19-25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10926489 10926489]
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Crystal structure of the beta-apical domain of the thermosome reveals structural plasticity in the protrusion region., Bosch G, Baumeister W, Essen LO, J Mol Biol. 2000 Aug 4;301(1):19-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10926489 10926489]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Thermoplasma acidophilum]]
[[Category: Thermoplasma acidophilum]]
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[[Category: thermosome]]
[[Category: thermosome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:22:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:47:38 2008''

Revision as of 08:47, 20 March 2008

Image:1e0r.jpg


PDB ID 1e0r

Drag the structure with the mouse to rotate
, resolution 2.8Å
Coordinates: save as pdb, mmCIF, xml



BETA-APICAL DOMAIN OF THERMOSOME


Overview

The crystal structure of the beta-apical domain of the thermosome, an archaeal group II chaperonin from Thermoplasma acidophilum, has been determined at 2.8 A resolution. The structure shows an invariant globular core from which a 25 A long protrusion emanates, composed of an elongated alpha-helix (H10) and a long extended stretch consisting of residues GluB245-ThrB253. A comparison with previous apical domain structures reveals a large segmental displacement of the protruding part of helix H10 via the hinge GluB276-ValB278. The region comprising residues GluB245-ThrB253 adopts an extended beta-like conformation rather than the alpha-helix seen in the alpha-apical domain. Consequently, it appears that the protrusions of the apical domains from group II chaperonins might assume a variety of context-dependent conformations during an open, substrate-accepting state of the chaperonin. Sequence variations in the protrusion regions that are found in the eukaryotic TRiC/CCT subunits may provide different structural propensities and hence serve different roles in substrate recognition.

About this Structure

1E0R is a Single protein structure of sequence from Thermoplasma acidophilum. Full crystallographic information is available from OCA.

Reference

Crystal structure of the beta-apical domain of the thermosome reveals structural plasticity in the protrusion region., Bosch G, Baumeister W, Essen LO, J Mol Biol. 2000 Aug 4;301(1):19-25. PMID:10926489

Page seeded by OCA on Thu Mar 20 10:47:38 2008

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