1e31

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[[Image:1e31.gif|left|200px]]<br /><applet load="1e31" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1e31.gif|left|200px]]
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caption="1e31, resolution 2.71&Aring;" />
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'''SURVIVIN DIMER H. SAPIENS'''<br />
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{{Structure
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|PDB= 1e31 |SIZE=350|CAPTION= <scene name='initialview01'>1e31</scene>, resolution 2.71&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=CO:COBALT (II) ION'>CO</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''SURVIVIN DIMER H. SAPIENS'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1E31 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=CO:'>CO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E31 OCA].
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1E31 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E31 OCA].
==Reference==
==Reference==
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Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions., Chantalat L, Skoufias DA, Kleman JP, Jung B, Dideberg O, Margolis RL, Mol Cell. 2000 Jul;6(1):183-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10949039 10949039]
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Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions., Chantalat L, Skoufias DA, Kleman JP, Jung B, Dideberg O, Margolis RL, Mol Cell. 2000 Jul;6(1):183-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10949039 10949039]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: zinc finger]]
[[Category: zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:23:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:48:44 2008''

Revision as of 08:48, 20 March 2008

Image:1e31.gif


PDB ID 1e31

Drag the structure with the mouse to rotate
, resolution 2.71Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



SURVIVIN DIMER H. SAPIENS


Overview

Survivin is a mitotic spindle-associated protein involved in linking mitotic spindle function to activation of apoptosis in mammalian cells. The structure of the full-length human survivin has been determined by X-ray crystallography to 2.7 A. Strikingly, the structure forms a very unusual bow tie-shaped dimer. It does not dimerize through a C-terminal coiled-coil, contrary to sequence analysis prediction. The C-terminal helices contain hydrophobic clusters with the potential for protein-protein interactions. The unusual shape and dimensions of survivin suggest it serves an adaptor function through its alpha-helical extensions.

About this Structure

1E31 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions., Chantalat L, Skoufias DA, Kleman JP, Jung B, Dideberg O, Margolis RL, Mol Cell. 2000 Jul;6(1):183-9. PMID:10949039

Page seeded by OCA on Thu Mar 20 10:48:44 2008

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