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4pla

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m (Protected "4pla" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==Crystal structure of phosphatidyl inositol 4-kinase II alpha in complex with ATP==
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<StructureSection load='4pla' size='340' side='right' caption='[[4pla]], [[Resolution|resolution]] 2.77&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4pla]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLA FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pla OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pla RCSB], [http://www.ebi.ac.uk/pdbsum/4pla PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Phosphoinositides are a class of phospholipids generated by the action of phosphoinositide kinases with key regulatory functions in eukaryotic cells. Here, we present the atomic structure of phosphatidylinositol 4-kinase type IIalpha (PI4K IIalpha), in complex with ATP solved by X-ray crystallography at 2.8 A resolution. The structure revealed a non-typical kinase fold that could be divided into N- and C-lobes with the ATP binding groove located in between. Surprisingly, a second ATP was found in a lateral hydrophobic pocket of the C-lobe. Molecular simulations and mutagenesis analysis revealed the membrane binding mode and the putative function of the hydrophobic pocket. Taken together, our results suggest a mechanism of PI4K IIalpha recruitment, regulation, and function at the membrane.
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The entry 4pla is ON HOLD until Paper Publication
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The crystal structure of the phosphatidylinositol 4-kinase IIalpha,Baumlova A, Chalupska D, Rozycki B, Jovic M, Wisniewski E, Klima M, Dubankova A, Kloer DP, Nencka R, Balla T, Boura E EMBO Rep. 2014 Aug 28. pii: e201438841. PMID:25168678<ref>PMID:25168678</ref>
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Authors: Baumlova, A., Chalupska, D., Boura, E.
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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Description: Crystal structure of phosphatidyl inositol 4-kinase II alpha in complex with ATP
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Baumlova, A.]]
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[[Category: Boura, E.]]
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[[Category: Chalupska, D.]]
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[[Category: 4-kinase]]
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[[Category: Atp]]
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[[Category: Hydrolase]]
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[[Category: Lipid]]
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[[Category: Phosphatidyl inositol]]
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[[Category: Transferase]]

Revision as of 09:52, 10 September 2014

Crystal structure of phosphatidyl inositol 4-kinase II alpha in complex with ATP

4pla, resolution 2.77Å

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