1e5p

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[[Image:1e5p.png|left|200px]]
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==CRYSTAL STRUCTURE OF APHRODISIN, A SEX PHEROMONE FROM FEMALE HAMSTER==
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<StructureSection load='1e5p' size='340' side='right' caption='[[1e5p]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1e5p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesocricetus_auratus Mesocricetus auratus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E5P FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MESOCRICETUS AURATUS APHRODISIN GENE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10036 Mesocricetus auratus])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e5p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e5p RCSB], [http://www.ebi.ac.uk/pdbsum/1e5p PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/1e5p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have solved the crystal structure of aphrodisin, a pheromonal protein inducing a copulatory behaviour in male hamster, using MAD methods with selenium, at 1.63 A resolution. The monomeric protein belongs to the lipocalin family, and possesses a disulfide bridge in a loop between strands 2 and 3. This disulfide bridge is characteristic of a family of lipocalins mainly identified in rodents, and is analogous to the fifth disulfide bridge of the long neurotoxins, such as alpha cobratoxin. An elongated electron density was found inside the buried cavity, which might represent a serendipitous ligand of unknown origin. The analysis of the water accessible surfaces of the side-chains bordering the cavity indicates that Phe76 may be the door for the natural ligand to access the cavity. This residue defines the entry of the cavity as belonging to the consensus for lipocalins. The face bearing Phe76 might also serve for the interaction with the receptor.
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{{STRUCTURE_1e5p| PDB=1e5p | SCENE= }}
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Crystal structure of aphrodisin, a sex pheromone from female hamster.,Vincent F, Lobel D, Brown K, Spinelli S, Grote P, Breer H, Cambillau C, Tegoni M J Mol Biol. 2001 Jan 19;305(3):459-69. PMID:11152604<ref>PMID:11152604</ref>
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===CRYSTAL STRUCTURE OF APHRODISIN, A SEX PHEROMONE FROM FEMALE HAMSTER===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_11152604}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1e5p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesocricetus_auratus Mesocricetus auratus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5P OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:011152604</ref><references group="xtra"/>
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[[Category: Mesocricetus auratus]]
[[Category: Mesocricetus auratus]]
[[Category: Brown, K.]]
[[Category: Brown, K.]]

Revision as of 10:53, 10 September 2014

CRYSTAL STRUCTURE OF APHRODISIN, A SEX PHEROMONE FROM FEMALE HAMSTER

1e5p, resolution 1.63Å

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