Proto-oncogene serine/threonine-protein kinase

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{{STRUCTURE_3cy2| PDB=3cy2 | SIZE=350| SCENE= |right|CAPTION=Pim-1 (grey) complex with consensus peptide (green), inhibitor and Cl- ion [[3cy2]] }}
{{STRUCTURE_3cy2| PDB=3cy2 | SIZE=350| SCENE= |right|CAPTION=Pim-1 (grey) complex with consensus peptide (green), inhibitor and Cl- ion [[3cy2]] }}
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===Pim1===
[[1xqz]], [[1ywv]] – hPim1 – human <br />
[[1xqz]], [[1ywv]] – hPim1 – human <br />

Revision as of 10:49, 23 September 2014

Template:STRUCTURE 3cy2

Proto-oncogene serine/threonine-protein kinase (Pim1) is implicated with a variety of cancers. Pim1 is involved in cell cycle progression, apoptosis, transcriptional activation and signaling pathways. Pim1 phosphorylates and inhibits proapoptotic proteins. Pim1 is phosphorylated on serine 261 (PSer). The consensus peptide (pimtide) ARKRRRHPSGPPTA binds strongly to Pim1.

Contents

3D Structures of pim-1

Updated on 23-September-2014

Pim1

1xqz, 1ywv – hPim1 – human
1yxs – hPim1 (mutant)
1xr1, 1yxt – hPim1 + AMPPNP
1yxu – hPim1 + AMP
1yxv, 3uix – hPim1 + quinoline derivative
1yxx – hPim1 + indole derivative
3a99 – hPim1 + phosphoaminophosphonic acid adenylate
2bzj, 2bzh, 2bzi, 2oi4, 3bwf – hPim1 (mutant) + organometallic ligand
1xws, 2o3p, 2o63, 2o64, 2o65, 3jxw, 3jy0, 3jya, 3r00, 3r01, 3r02, 3r04, 3vbq, 3vbt, 3vbv, 3vbw, 3vbx, 3vby, 3vc4, 4dtk, 3umx, 4enx, 4eny, 3umw, 4as0, 4alu, 4alv, 4alw, 4bzn, 4bzo, 4ll5, 4lm5 – hPim1 + inhibitor
2j2i – hPim1 (mutant)+ inhibitor

Pim1 complex with consensus peptide

2c3i, 4gw8 – hPim1 (mutant) + inhibitor + consensus peptide
2bzk – hPim1 (mutant)+ AMPPNP + consensus peptide
2bil, 3cxw, 3cy2, 3cy3, 3jpv, 3qf9 – hPim1 + inhibitor + consensus peptide
3ma3 – hPim1 + inhibitor + PSer + consensus peptide

Pim1 containing phosphorylated Ser 261

1yhs – hPim1 + PSer + staurosporine
1yi3, 2bik, 2obj, 3bgp, 3bgq, 3bgz, 3dcv, 3f2a, 2xix, 2xiy, 2xiz, 2xj0, 2xj1, 2xj2, 3t9i, 4a7c – hPim1 + PSer + inhibitor
1yi4 – hPim1 + PSer + adenosine

Pim1 raf

See Serine/threonine protein kinase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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