4c4a
From Proteopedia
(Difference between revisions)
| Line 6: | Line 6: | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c4a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c4a RCSB], [http://www.ebi.ac.uk/pdbsum/4c4a PDBsum]</span></td></tr> | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c4a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c4a RCSB], [http://www.ebi.ac.uk/pdbsum/4c4a PDBsum]</span></td></tr> | ||
<table> | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Protein arginine methyltransferase 7 (PRMT7) is a type III arginine methyltransferase which has been implicated in several biological processes such as transcriptional regulation, DNA damage repair, RNA splicing, cell differentiation and metastasis. PRMT7 is a unique but less characterized member of the family of PRMTs. The crystal structure of full-length PRMT7 from Mus musculus refined at 1.7 A resolution is described. The PRMT7 structure is composed of two catalytic modules in tandem forming a pseudo-dimer and contains only one AdoHcy molecule bound to the N-terminal module. The high-resolution crystal structure presented here revealed several structural features showing that the second active site is frozen in an inactive state by a conserved zinc finger located at the junction between the two PRMT modules and by the collapse of two degenerated AdoMet-binding loops. | ||
| + | |||
| + | Structural insight into arginine methylation by the mouse protein arginine methyltransferase 7: a zinc finger freezes the mimic of the dimeric state into a single active site.,Cura V, Troffer-Charlier N, Wurtz JM, Bonnefond L, Cavarelli J Acta Crystallogr D Biol Crystallogr. 2014 Sep 1;70(Pt 9):2401-12. doi:, 10.1107/S1399004714014278. Epub 2014 Aug 29. PMID:25195753<ref>PMID:25195753</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 06:28, 24 September 2014
Crystal structure of mouse protein arginine methyltransferase 7 in complex with SAH
| |||||||||||
