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4u6v
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| - | ''' | + | ==Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody== |
| + | <StructureSection load='4u6v' size='340' side='right' caption='[[4u6v]], [[Resolution|resolution]] 2.56Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4u6v]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U6V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U6V FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u6v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u6v RCSB], [http://www.ebi.ac.uk/pdbsum/4u6v PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | MEDI4893 is a neutralizing human monoclonal antibody that targets alpha toxin (AT), and is currently undergoing evaluation in the field of Staphylococcus aureus-mediated diseases. We have solved the crystal structure of MEDI4893 Fab bound to monomeric AT at a resolution of 2.56 A, and further characterized its epitope using various engineered AT variants. We have found that MEDI4893 recognizes a novel epitope in AT so-called rim domain, and exerts its neutralizing effect through a dual mechanism. More particularly, MEDI4893 not only sterically blocks binding of AT to its cell receptor, but also prevents it from adopting a lytic heptameric trans-membrane conformation. | ||
| - | + | Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody.,Oganesyan V, Peng L, Damschroder MM, Cheng L, Sadowska A, Tkaczyk C, Sellman BR, Wu H, Dall'Acqua WF J Biol Chem. 2014 Sep 10. pii: jbc.M114.601328. PMID:25210036<ref>PMID:25210036</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Acqua, W F.Dall.]] | ||
| + | [[Category: Cheng, L.]] | ||
| + | [[Category: Damschroder, M M.]] | ||
| + | [[Category: Oganesyan, V Y.]] | ||
| + | [[Category: Peng, L.]] | ||
| + | [[Category: Sadowska, A.]] | ||
| + | [[Category: Sellman, B.]] | ||
| + | [[Category: Tkaczyk, C.]] | ||
| + | [[Category: Wu, H.]] | ||
| + | [[Category: Alpha toxin]] | ||
| + | [[Category: Fab]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Mutagenesis]] | ||
| + | [[Category: Staphylococcus aureus]] | ||
Revision as of 06:43, 24 September 2014
Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody
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