1efh
From Proteopedia
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| - | [[Image:1efh.jpg|left|200px]] | + | [[Image:1efh.jpg|left|200px]] |
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| - | '''CRYSTAL STRUCTURE OF THE HUMAN HYDROXYSTEROID SULFOTRANSFERASE IN THE PRESENCE OF PAP''' | + | {{Structure |
| + | |PDB= 1efh |SIZE=350|CAPTION= <scene name='initialview01'>1efh</scene>, resolution 2.40Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=A3P:ADENOSINE-3'-5'-DIPHOSPHATE'>A3P</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Alcohol_sulfotransferase Alcohol sulfotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.2.2 2.8.2.2] | ||
| + | |GENE= CDNA LIBRARY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''CRYSTAL STRUCTURE OF THE HUMAN HYDROXYSTEROID SULFOTRANSFERASE IN THE PRESENCE OF PAP''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1EFH is a [ | + | 1EFH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EFH OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of SULT2A3, human hydroxysteroid sulfotransferase., Pedersen LC, Petrotchenko EV, Negishi M, FEBS Lett. 2000 Jun 9;475(1):61-4. PMID:[http:// | + | Crystal structure of SULT2A3, human hydroxysteroid sulfotransferase., Pedersen LC, Petrotchenko EV, Negishi M, FEBS Lett. 2000 Jun 9;475(1):61-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10854859 10854859] |
[[Category: Alcohol sulfotransferase]] | [[Category: Alcohol sulfotransferase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: dhea]] | [[Category: dhea]] | ||
[[Category: hydroxysteroid]] | [[Category: hydroxysteroid]] | ||
| - | [[Category: | + | [[Category: pap]] |
[[Category: sulfotransferase]] | [[Category: sulfotransferase]] | ||
[[Category: sult2a3]] | [[Category: sult2a3]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:54:56 2008'' |
Revision as of 08:54, 20 March 2008
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| , resolution 2.40Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | CDNA LIBRARY (Homo sapiens) | ||||||
| Activity: | Alcohol sulfotransferase, with EC number 2.8.2.2 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF THE HUMAN HYDROXYSTEROID SULFOTRANSFERASE IN THE PRESENCE OF PAP
Contents |
Overview
The crystal structure of SULT2A3 human hydroxysteroid sulfotransferase has been solved at 2.4 A resolution in the presence of 3'-phosphoadenosine 5'-phosphate (PAP). The overall structure is similar to those of SULT1 enzymes such as estrogen sulfotransferase and the PAP binding site is conserved, however, significant differences exist in the positions of loops Pro14-Ser20, Glu79-Ile82 and Tyr234-Gln244 in the substrate binding pocket. Moreover, protein interaction in the crystal structure has revealed a possible dimer-directed conformational alteration that may regulate the SULT activity.
Disease
Known diseases associated with this structure: Histidinemia OMIM:[609457], Selective T-cell defect OMIM:[176947]
About this Structure
1EFH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of SULT2A3, human hydroxysteroid sulfotransferase., Pedersen LC, Petrotchenko EV, Negishi M, FEBS Lett. 2000 Jun 9;475(1):61-4. PMID:10854859
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