4on3
From Proteopedia
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| - | ''' | + | ==Crystal structure of human sorting nexin 10 (SNX10)== |
| - | + | <StructureSection load='4on3' size='340' side='right' caption='[[4on3]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4on3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ON3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ON3 FirstGlance]. <br> | |
| - | + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene><br> | |
| - | + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4on3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4on3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4on3 RCSB], [http://www.ebi.ac.uk/pdbsum/4on3 PDBsum]</span></td></tr> | |
| - | + | <table> | |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/SNX10_HUMAN SNX10_HUMAN]] Autosomal recessive malignant osteopetrosis. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:22499339</ref> <ref>PMID:23123320</ref> <ref>PMID:23280965</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SNX10_HUMAN SNX10_HUMAN]] Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption.<ref>PMID:17012226</ref> <ref>PMID:21844891</ref> <ref>PMID:22499339</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Liu, J.]] | ||
| + | [[Category: Wang, Q.]] | ||
| + | [[Category: Xu, J.]] | ||
| + | [[Category: Xu, T.]] | ||
| + | [[Category: Phox-homology domain]] | ||
| + | [[Category: Protein transport]] | ||
| + | [[Category: Sorting nexin]] | ||
Revision as of 10:46, 24 September 2014
Crystal structure of human sorting nexin 10 (SNX10)
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