1epf

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[[Image:1epf.gif|left|200px]]<br /><applet load="1epf" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1epf.gif|left|200px]]
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caption="1epf, resolution 1.85&Aring;" />
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'''CRYSTAL STRUCTURE OF THE TWO N-TERMINAL IMMUNOGLOBULIN DOMAINS OF THE NEURAL CELL ADHESION MOLECULE (NCAM)'''<br />
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{{Structure
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|PDB= 1epf |SIZE=350|CAPTION= <scene name='initialview01'>1epf</scene>, resolution 1.85&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF THE TWO N-TERMINAL IMMUNOGLOBULIN DOMAINS OF THE NEURAL CELL ADHESION MOLECULE (NCAM)'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1EPF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPF OCA].
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1EPF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPF OCA].
==Reference==
==Reference==
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Structural basis of cell-cell adhesion by NCAM., Kasper C, Rasmussen H, Kastrup JS, Ikemizu S, Jones EY, Berezin V, Bock E, Larsen IK, Nat Struct Biol. 2000 May;7(5):389-93. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10802736 10802736]
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Structural basis of cell-cell adhesion by NCAM., Kasper C, Rasmussen H, Kastrup JS, Ikemizu S, Jones EY, Berezin V, Bock E, Larsen IK, Nat Struct Biol. 2000 May;7(5):389-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10802736 10802736]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: ncam]]
[[Category: ncam]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:30:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:58:38 2008''

Revision as of 08:58, 20 March 2008

Image:1epf.gif


PDB ID 1epf

Drag the structure with the mouse to rotate
, resolution 1.85Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF THE TWO N-TERMINAL IMMUNOGLOBULIN DOMAINS OF THE NEURAL CELL ADHESION MOLECULE (NCAM)


Overview

The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell-cell recognition and adhesion via a homophilic interaction. NCAM plays a key role during development and regeneration of the nervous system and is involved in synaptic plasticity associated with memory and learning. The 1.85 A crystal structure of the two N-terminal extracellular domains of NCAM reported here provides a structural basis for the homophilic interaction. The molecular packing of the two-domain structure reveals a cross shaped antiparallel dimer, and provides fundamental insight into trans-cellular recognition mediated by NCAM.

About this Structure

1EPF is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural basis of cell-cell adhesion by NCAM., Kasper C, Rasmussen H, Kastrup JS, Ikemizu S, Jones EY, Berezin V, Bock E, Larsen IK, Nat Struct Biol. 2000 May;7(5):389-93. PMID:10802736

Page seeded by OCA on Thu Mar 20 10:58:38 2008

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