This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2iuk
From Proteopedia
| Line 31: | Line 31: | ||
[[Category: soybean lipoxygenase-d]] | [[Category: soybean lipoxygenase-d]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 17:16:10 2007'' |
Revision as of 15:11, 30 October 2007
|
CRYSTAL STRUCTURE OF SOYBEAN LIPOXYGENASE-D
Overview
The lipoxygenase family of lipid-peroxidizing, nonheme iron dioxygenases, form products that are precursors for diverse physiological processes in, both plants and animals. In soybean (Glycine max), five vegetative, isoforms, VLX-A, VLX-B, VLX-C, VLX-D, VLX-E, and four seed isoforms LOX-1, LOX-2, LOX-3a, LOX-3b have been identified. In this study, we determined, the crystal structures of the substrate-free forms of two major vegetative, isoforms, with distinct enzymatic characteristics, VLX-B and VLX-D. Their, structures are similar to the two seed isoforms, LOX-1 and LOX-3, having, two domains with similar secondary structural elements: a beta-barrel, N-terminal domain containing highly flexible loops and an alpha-helix-rich, C-terminal catalytic domain. Detailed comparison of the ... [(full description)]
About this Structure
2IUK is a [Single protein] structure of sequence from [Glycine max] with FE as [ligand]. Active as [Lipoxygenase], with EC number [1.13.11.12]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structures of vegetative soybean lipoxygenase VLX-B and VLX-D, and comparisons with seed isoforms LOX-1 and LOX-3., Youn B, Sellhorn GE, Mirchel RJ, Gaffney BJ, Grimes HD, Kang C, Proteins. 2006 Dec 1;65(4):1008-20. PMID:17022084
Page seeded by OCA on Tue Oct 30 17:16:10 2007
