1eqk

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[[Image:1eqk.gif|left|200px]]<br /><applet load="1eqk" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1eqk.gif|left|200px]]
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caption="1eqk" />
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'''SOLUTION STRUCTURE OF ORYZACYSTATIN-I, A CYSTEINE PROTEINASE INHIBITOR OF THE RICE, ORYZA SATIVA L. JAPONICA'''<br />
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{{Structure
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|PDB= 1eqk |SIZE=350|CAPTION= <scene name='initialview01'>1eqk</scene>
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''SOLUTION STRUCTURE OF ORYZACYSTATIN-I, A CYSTEINE PROTEINASE INHIBITOR OF THE RICE, ORYZA SATIVA L. JAPONICA'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1EQK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Oryza_sativa_japonica_group Oryza sativa japonica group]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EQK OCA].
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1EQK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryza_sativa_japonica_group Oryza sativa japonica group]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EQK OCA].
==Reference==
==Reference==
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Three-dimensional solution structure of oryzacystatin-I, a cysteine proteinase inhibitor of the rice, Oryza sativa L. japonica., Nagata K, Kudo N, Abe K, Arai S, Tanokura M, Biochemistry. 2000 Dec 5;39(48):14753-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11101290 11101290]
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Three-dimensional solution structure of oryzacystatin-I, a cysteine proteinase inhibitor of the rice, Oryza sativa L. japonica., Nagata K, Kudo N, Abe K, Arai S, Tanokura M, Biochemistry. 2000 Dec 5;39(48):14753-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11101290 11101290]
[[Category: Oryza sativa japonica group]]
[[Category: Oryza sativa japonica group]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Nagata, K.]]
[[Category: Nagata, K.]]
[[Category: Tanokura, M.]]
[[Category: Tanokura, M.]]
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[[Category: alpha and beta proteins]]
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[[Category: alpha and beta protein]]
[[Category: cystatin-like fold]]
[[Category: cystatin-like fold]]
[[Category: cystatin/monellin superfamily]]
[[Category: cystatin/monellin superfamily]]
[[Category: phytocystatin family]]
[[Category: phytocystatin family]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:30:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:59:07 2008''

Revision as of 08:59, 20 March 2008


PDB ID 1eqk

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SOLUTION STRUCTURE OF ORYZACYSTATIN-I, A CYSTEINE PROTEINASE INHIBITOR OF THE RICE, ORYZA SATIVA L. JAPONICA


Overview

The three-dimensional structure of oryzacystatin-I, a cysteine proteinase inhibitor of the rice, Oryza sativa L. japonica, has been determined in solution at pH 6.8 and 25 degrees C by (1)H and (15)N NMR spectroscopy. The main body (Glu13-Asp97) of oryzacystatin-I is well-defined and consists of an alpha-helix and a five-stranded antiparallel beta-sheet, while the N- and C-terminal regions (Ser2-Val12 and Ala98-Ala102) are less defined. The helix-sheet architechture of oryzacystatin-I is stabilized by a hydrophobic cluster formed between the alpha-helix and the beta-sheet and is considerably similar to that of monellin, a sweet-tasting protein from an African berry, as well as those of the animal cystatins studied, e.g., chicken egg white cystatin and human stefins A and B (also referred to as human cystatins A and B). Detailed structural comparison indicates that oryzacystatin-I is more similar to chicken cystatin, which belongs to the type-2 animal cystatins, than to human stefins A and B, which belong to the type-1 animal cystatins, despite different loop length.

About this Structure

1EQK is a Single protein structure of sequence from Oryza sativa japonica group. Full crystallographic information is available from OCA.

Reference

Three-dimensional solution structure of oryzacystatin-I, a cysteine proteinase inhibitor of the rice, Oryza sativa L. japonica., Nagata K, Kudo N, Abe K, Arai S, Tanokura M, Biochemistry. 2000 Dec 5;39(48):14753-60. PMID:11101290

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