1erg
From Proteopedia
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| - | [[Image:1erg.gif|left|200px]] | + | [[Image:1erg.gif|left|200px]] |
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| - | '''THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE EXTRACELLULAR REGION OF THE COMPLEMENT REGULATORY PROTEIN, CD59, A NEW CELL SURFACE PROTEIN DOMAIN RELATED TO NEUROTOXINS''' | + | {{Structure |
| + | |PDB= 1erg |SIZE=350|CAPTION= <scene name='initialview01'>1erg</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE EXTRACELLULAR REGION OF THE COMPLEMENT REGULATORY PROTEIN, CD59, A NEW CELL SURFACE PROTEIN DOMAIN RELATED TO NEUROTOXINS''' | ||
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==Overview== | ==Overview== | ||
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==Disease== | ==Disease== | ||
| - | Known | + | Known disease associated with this structure: CD59 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=107271 107271]] |
==About this Structure== | ==About this Structure== | ||
| - | 1ERG is a [ | + | 1ERG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ERG OCA]. |
==Reference== | ==Reference== | ||
| - | Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins., Kieffer B, Driscoll PC, Campbell ID, Willis AC, van der Merwe PA, Davis SJ, Biochemistry. 1994 Apr 19;33(15):4471-82. PMID:[http:// | + | Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins., Kieffer B, Driscoll PC, Campbell ID, Willis AC, van der Merwe PA, Davis SJ, Biochemistry. 1994 Apr 19;33(15):4471-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7512825 7512825] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: complement factor]] | [[Category: complement factor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:59:17 2008'' |
Revision as of 08:59, 20 March 2008
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THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE EXTRACELLULAR REGION OF THE COMPLEMENT REGULATORY PROTEIN, CD59, A NEW CELL SURFACE PROTEIN DOMAIN RELATED TO NEUROTOXINS
Contents |
Overview
The cell surface antigen CD59 is an inhibitor of complement-mediated lysis and a member of the Ly6 superfamily (Ly6SF) of cysteine-rich cell-surface molecules whose sequences are related to those of snake venom neurotoxins. The three-dimensional solution structure of a recombinant form of the extracellular region of the molecule (residues 1-70 of the mature protein; sCD59) has been solved by 2D NMR methods. sCD59 is a relatively flat, disk-shaped molecule consisting of a two-standed beta-sheet finger loosely packed against a protein core formed by a three-stranded beta-sheet and a short helix. Structure calculations allowed an unambiguous assignment of the disulfide-bonded cysteine pairs as 3-26, 6-13, 19-39, 45-63, and 64-69. The topology of sCD59 is similar to that of the snake venom neurotoxins and consistent with an evolutionary relationship existing between the Ly6SF and the neurotoxins.
Disease
Known disease associated with this structure: CD59 deficiency OMIM:[107271]
About this Structure
1ERG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins., Kieffer B, Driscoll PC, Campbell ID, Willis AC, van der Merwe PA, Davis SJ, Biochemistry. 1994 Apr 19;33(15):4471-82. PMID:7512825
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