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1erk

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[[Image:1erk.gif|left|200px]]<br /><applet load="1erk" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1erk.gif|left|200px]]
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caption="1erk, resolution 2.3&Aring;" />
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'''STRUCTURE OF SIGNAL-REGULATED KINASE'''<br />
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{{Structure
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|PDB= 1erk |SIZE=350|CAPTION= <scene name='initialview01'>1erk</scene>, resolution 2.3&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= ERK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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}}
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'''STRUCTURE OF SIGNAL-REGULATED KINASE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1ERK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ERK OCA].
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1ERK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ERK OCA].
==Reference==
==Reference==
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Atomic structure of the MAP kinase ERK2 at 2.3 A resolution., Zhang F, Strand A, Robbins D, Cobb MH, Goldsmith EJ, Nature. 1994 Feb 24;367(6465):704-11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8107865 8107865]
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Atomic structure of the MAP kinase ERK2 at 2.3 A resolution., Zhang F, Strand A, Robbins D, Cobb MH, Goldsmith EJ, Nature. 1994 Feb 24;367(6465):704-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8107865 8107865]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transferase]]
[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:30:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:59:21 2008''

Revision as of 08:59, 20 March 2008

Image:1erk.gif


PDB ID 1erk

Drag the structure with the mouse to rotate
, resolution 2.3Å
Gene: ERK2 (Rattus norvegicus)
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF SIGNAL-REGULATED KINASE


Overview

The structure of the MAP kinase ERK2, a ubiquitous protein kinase target for regulation by Ras and Raf, has been solved in its unphosphorylated low-activity conformation to a resolution of 2.3 A. The two domains of unphosphorylated ERK2 are farther apart than in the active conformation of cAMP-dependent protein kinase and the peptide-binding site is blocked by tyrosine 185, one of the two residues that are phosphorylated in the active enzyme. Activation of ERK2 is thus likely to involve both global and local conformational changes.

About this Structure

1ERK is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Atomic structure of the MAP kinase ERK2 at 2.3 A resolution., Zhang F, Strand A, Robbins D, Cobb MH, Goldsmith EJ, Nature. 1994 Feb 24;367(6465):704-11. PMID:8107865

Page seeded by OCA on Thu Mar 20 10:59:21 2008

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