1hwq
From Proteopedia
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| - | [[ | + | ==SOLUTION STRUCTURE OF THE VS RIBOZYME SUBSTRATE STEM-LOOP== |
| + | <StructureSection load='1hwq' size='340' side='right' caption='[[1hwq]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1hwq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HWQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HWQ FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hwq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hwq RCSB], [http://www.ebi.ac.uk/pdbsum/1hwq PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The VS ribozyme is a 154 nucleotide sequence found in certain natural strains of Neurospora. The RNA can be divided into a substrate and a catalytic domain. Here we present the solution structure of the substrate RNA that is cleaved in a trans reaction by the catalytic domain in the presence of Mg2+. The 30 nucleotide substrate RNA forms a compact helix capped by a flexible loop. The cleavage site bulge contains three non-canonical base-pairs, including an A+.C pair with a protonated adenine. This adenine (A622) is a pH controlled conformational switch that opens up the internal loop at higher pH. The possible significance of this switch for substrate recognition and cleavage is discussed. | ||
| - | + | A pH controlled conformational switch in the cleavage site of the VS ribozyme substrate RNA.,Flinders J, Dieckmann T J Mol Biol. 2001 May 11;308(4):665-79. PMID:11350168<ref>PMID:11350168</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
*[[Ribozyme|Ribozyme]] | *[[Ribozyme|Ribozyme]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Dieckmann, T.]] | [[Category: Dieckmann, T.]] | ||
[[Category: Flinders, J C.]] | [[Category: Flinders, J C.]] | ||
Revision as of 11:13, 28 September 2014
SOLUTION STRUCTURE OF THE VS RIBOZYME SUBSTRATE STEM-LOOP
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