1ik3

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[[Image:1ik3.png|left|200px]]
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==LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC ACID==
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<StructureSection load='1ik3' size='340' side='right' caption='[[1ik3]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ik3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Glycine_max Glycine max]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IK3 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=11O:(TRANS-12,13-EPOXY)-11-HYDROXY-9(Z)-OCTADECENOIC+ACID'>11O</scene>, <scene name='pdbligand=13R:13(R)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC+ACID'>13R</scene>, <scene name='pdbligand=13S:13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC+ACID'>13S</scene>, <scene name='pdbligand=9OH:(TRANS-12,13-EPOXY)-9-HYDROXY-10(E)-OCTADECENOIC+ACID'>9OH</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene><br>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lipoxygenase Lipoxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.12 1.13.11.12] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ik3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ik3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ik3 RCSB], [http://www.ebi.ac.uk/pdbsum/1ik3 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ik/1ik3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Polyunsaturated fatty acid metabolism is governed primarily by two enzymes, prostaglandin H synthase and lipoxygenase. The crystal structure of the metastable product-oxidized purple form of soybean lipoxygenase-3 was determined at 2.0 A resolution. The data reveal that the chromophore corresponds to an iron-peroxide complex, a potential intermediate in the catalyzed reaction. A significant alteration of the iron site accompanies the formation of the complex. The structure, the first for a fatty acid-lipoxygenase complex, also reveals an unexpected mode of binding, and identifies amino acid residues that may play significant roles in catalysis, regio- and stereoselectivity.
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{{STRUCTURE_1ik3| PDB=1ik3 | SCENE= }}
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Three-dimensional structure of a purple lipoxygenase.,Skrzypczak-Jankun E, Bross RA, Carroll RT, Dunham WR, Funk MO Jr J Am Chem Soc. 2001 Nov 7;123(44):10814-20. PMID:11686682<ref>PMID:11686682</ref>
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===LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC ACID===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_11686682}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1ik3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Glycine_max Glycine max]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IK3 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:011686682</ref><references group="xtra"/>
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[[Category: Glycine max]]
[[Category: Glycine max]]
[[Category: Lipoxygenase]]
[[Category: Lipoxygenase]]

Revision as of 11:24, 28 September 2014

LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC ACID

1ik3, resolution 2.00Å

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OCA

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