1gu2

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[[Image:1gu2.png|left|200px]]
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==CRYSTAL STRUCTURE OF OXIDIZED CYTOCHROME C'' FROM METHYLOPHILUS METHYLOTROPHUS==
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<StructureSection load='1gu2' size='340' side='right' caption='[[1gu2]], [[Resolution|resolution]] 1.19&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1gu2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GU2 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEC:HEME+C'>HEC</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e8e|1e8e]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gu2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gu2 RCSB], [http://www.ebi.ac.uk/pdbsum/1gu2 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gu/1gu2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structures of the oxidized and reduced forms of cytochrome c" from Methylophilus methylotrophus were solved from X-ray synchrotron data to atomic resolution. The overall fold of the molecule in the two redox states is very similar and is comparable to that of the oxygen-binding protein from the purple phototrophic bacterium Rhodobacter sphaeroides. However, significant modifications occur near the haem group, in particular the detachment from axial binding of His95 observed upon reduction as well as the adoption of different conformations of some protonatable residues that form a possible proton path from the haem pocket to the protein surface. These changes are associated with the previously well characterized redox-Bohr behaviour of this protein. Furthermore they provide a model for one of the presently proposed mechanisms of proton translocation in the much more complex protein cytochrome c oxidase.
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{{STRUCTURE_1gu2| PDB=1gu2 | SCENE= }}
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Structural evidence for a proton transfer pathway coupled with haem reduction of cytochrome c" from Methylophilus methylotrophus.,Enguita FJ, Pohl E, Turner DL, Santos H, Carrondo MA J Biol Inorg Chem. 2006 Mar;11(2):189-96. Epub 2005 Dec 10. PMID:16341897<ref>PMID:16341897</ref>
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===CRYSTAL STRUCTURE OF OXIDIZED CYTOCHROME C'' FROM METHYLOPHILUS METHYLOTROPHUS===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_16341897}}
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==About this Structure==
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[[1gu2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GU2 OCA].
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==See Also==
==See Also==
*[[Cytochrome c|Cytochrome c]]
*[[Cytochrome c|Cytochrome c]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016341897</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Methylophilus methylotrophus]]
[[Category: Methylophilus methylotrophus]]
[[Category: Carrondo, M A.]]
[[Category: Carrondo, M A.]]

Revision as of 11:33, 28 September 2014

CRYSTAL STRUCTURE OF OXIDIZED CYTOCHROME C FROM METHYLOPHILUS METHYLOTROPHUS

1gu2, resolution 1.19Å

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