1hnz
From Proteopedia
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| - | [[ | + | ==STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH HYGROMYCIN B== |
| + | <StructureSection load='1hnz' size='340' side='right' caption='[[1hnz]], [[Resolution|resolution]] 3.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1hnz]] is a 22 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HNZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HNZ FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYG:HYGROMYCIN+B'>HYG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br> | ||
| + | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qd7|1qd7]], [[1fjf|1fjf]], [[1fjg|1fjg]], [[1hnw|1hnw]], [[1hnx|1hnx]]</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hnz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hnz RCSB], [http://www.ebi.ac.uk/pdbsum/1hnz PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hn/1hnz_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We have used the recently determined atomic structure of the 30S ribosomal subunit to determine the structures of its complexes with the antibiotics tetracycline, pactamycin, and hygromycin B. The antibiotics bind to discrete sites on the 30S subunit in a manner consistent with much but not all biochemical data. For each of these antibiotics, interactions with the 30S subunit suggest a mechanism for its effects on ribosome function. | ||
| - | + | The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit.,Brodersen DE, Clemons WM Jr, Carter AP, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V Cell. 2000 Dec 22;103(7):1143-54. PMID:11163189<ref>PMID:11163189</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
| - | *[[Ribosomal protein S10|Ribosomal protein S10]] | ||
| - | *[[Ribosomal protein S11|Ribosomal protein S11]] | ||
| - | *[[Ribosomal protein S12|Ribosomal protein S12]] | ||
| - | *[[Ribosomal protein S13|Ribosomal protein S13]] | ||
| - | *[[Ribosomal protein S14|Ribosomal protein S14]] | ||
| - | *[[Ribosomal protein S15|Ribosomal protein S15]] | ||
| - | *[[Ribosomal protein S16|Ribosomal protein S16]] | ||
| - | *[[Ribosomal protein S17|Ribosomal protein S17]] | ||
| - | *[[Ribosomal protein S18|Ribosomal protein S18]] | ||
| - | *[[Ribosomal protein S19|Ribosomal protein S19]] | ||
| - | *[[Ribosomal protein S2|Ribosomal protein S2]] | ||
| - | *[[Ribosomal protein S20|Ribosomal protein S20]] | ||
| - | *[[Ribosomal protein S3|Ribosomal protein S3]] | ||
| - | *[[Ribosomal protein S4|Ribosomal protein S4]] | ||
| - | *[[Ribosomal protein S5|Ribosomal protein S5]] | ||
| - | *[[Ribosomal protein S6|Ribosomal protein S6]] | ||
| - | *[[Ribosomal protein S7|Ribosomal protein S7]] | ||
| - | *[[Ribosomal protein S8|Ribosomal protein S8]] | ||
| - | *[[Ribosomal protein S9|Ribosomal protein S9]] | ||
*[[Ribosomal protein THX|Ribosomal protein THX]] | *[[Ribosomal protein THX|Ribosomal protein THX]] | ||
*[[Ribosome|Ribosome]] | *[[Ribosome|Ribosome]] | ||
| - | + | *[[Ribosome 3D structures|Ribosome 3D structures]] | |
| - | == | + | == References == |
| - | < | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Thermus thermophilus]] | [[Category: Thermus thermophilus]] | ||
[[Category: Brodersen, D E.]] | [[Category: Brodersen, D E.]] | ||
Revision as of 11:50, 28 September 2014
STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH HYGROMYCIN B
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