1evo
From Proteopedia
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| - | [[Image:1evo.gif|left|200px]] | + | [[Image:1evo.gif|left|200px]] |
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| - | '''NMR OBSERVATION OF A NOVEL C-TETRAD''' | + | {{Structure |
| + | |PDB= 1evo |SIZE=350|CAPTION= <scene name='initialview01'>1evo</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''NMR OBSERVATION OF A NOVEL C-TETRAD''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1EVO is a [ | + | 1EVO is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EVO OCA]. |
==Reference== | ==Reference== | ||
| - | NMR observation of a novel C-tetrad in the structure of the SV40 repeat sequence GGGCGG., Patel PK, Bhavesh NS, Hosur RV, Biochem Biophys Res Commun. 2000 Apr 21;270(3):967-71. PMID:[http:// | + | NMR observation of a novel C-tetrad in the structure of the SV40 repeat sequence GGGCGG., Patel PK, Bhavesh NS, Hosur RV, Biochem Biophys Res Commun. 2000 Apr 21;270(3):967-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10772934 10772934] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Bhavesh, N S.]] | [[Category: Bhavesh, N S.]] | ||
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[[Category: sv40]] | [[Category: sv40]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:00:54 2008'' |
Revision as of 09:00, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR OBSERVATION OF A NOVEL C-TETRAD
Overview
We report the NMR structure of the DNA sequence d-TGGGCGGT in Na(+) solutions at neutral pH, containing a repeat sequence from SV40 viral genome. The structure is a novel quadruplex incorporating the C-tetrad formed by symmetrical pairing of four Cs via NH(2)&bond;O(2) H-bonds in a plane. The C-tetrad has a wider cavity compared to G-tetrads and stacks well over the adjacent G4-tetrad, but poorly on the G6 tetrad. The quadruplex helix is largely underwound by 8-10 degrees compared to B-DNA except at the C5-G6 step. To our knowledge this is the first report of C-tetrad formation in DNA structures, and would be of significance from the point of view of both structural diversity and specific recognition.
About this Structure
1EVO is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
NMR observation of a novel C-tetrad in the structure of the SV40 repeat sequence GGGCGG., Patel PK, Bhavesh NS, Hosur RV, Biochem Biophys Res Commun. 2000 Apr 21;270(3):967-71. PMID:10772934
Page seeded by OCA on Thu Mar 20 11:00:54 2008
