1exb

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[[Image:1exb.gif|left|200px]]<br /><applet load="1exb" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1exb.gif|left|200px]]
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caption="1exb, resolution 2.1&Aring;" />
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'''STRUCTURE OF THE CYTOPLASMIC BETA SUBUNIT-T1 ASSEMBLY OF VOLTAGE-DEPENDENT K CHANNELS'''<br />
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{{Structure
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|PDB= 1exb |SIZE=350|CAPTION= <scene name='initialview01'>1exb</scene>, resolution 2.1&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NDP:NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE'>NDP</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''STRUCTURE OF THE CYTOPLASMIC BETA SUBUNIT-T1 ASSEMBLY OF VOLTAGE-DEPENDENT K CHANNELS'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1EXB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=NDP:'>NDP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXB OCA].
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1EXB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXB OCA].
==Reference==
==Reference==
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Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels., Gulbis JM, Zhou M, Mann S, MacKinnon R, Science. 2000 Jul 7;289(5476):123-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10884227 10884227]
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Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels., Gulbis JM, Zhou M, Mann S, MacKinnon R, Science. 2000 Jul 7;289(5476):123-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10884227 10884227]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: oxidoreductase]]
[[Category: oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:32:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:01:27 2008''

Revision as of 09:01, 20 March 2008

Image:1exb.gif


PDB ID 1exb

Drag the structure with the mouse to rotate
, resolution 2.1Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF THE CYTOPLASMIC BETA SUBUNIT-T1 ASSEMBLY OF VOLTAGE-DEPENDENT K CHANNELS


Overview

The structure of the cytoplasmic assembly of voltage-dependent K+ channels was solved by x-ray crystallography at 2.1 angstrom resolution. The assembly includes the cytoplasmic (T1) domain of the integral membrane alpha subunit together with the oxidoreductase beta subunit in a fourfold symmetric T1(4)beta4 complex. An electrophysiological assay showed that this complex is oriented with four T1 domains facing the transmembrane pore and four beta subunits facing the cytoplasm. The transmembrane pore communicates with the cytoplasm through lateral, negatively charged openings above the T1(4)beta4 complex. The inactivation peptides of voltage-dependent K(+) channels reach their site of action by entering these openings.

About this Structure

1EXB is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels., Gulbis JM, Zhou M, Mann S, MacKinnon R, Science. 2000 Jul 7;289(5476):123-7. PMID:10884227

Page seeded by OCA on Thu Mar 20 11:01:27 2008

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