1jp6

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[[Image:1jp6.png|left|200px]]
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==Sperm Whale met-Myoglobin (room temperature; room pressure)==
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<StructureSection load='1jp6' size='340' side='right' caption='[[1jp6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1jp6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JP6 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jp8|1jp8]], [[1jp9|1jp9]], [[1jpb|1jpb]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jp6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jp6 RCSB], [http://www.ebi.ac.uk/pdbsum/1jp6 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jp/1jp6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pressures in the 100 MPa range are known to have an enormous number of effects on the action of proteins, but straightforward means for determining the structural basis of these effects have been lacking. Here, crystallography has been used to probe effects of pressure on sperm whale myoglobin structure. A comparison of pressure effects with those seen at low pH suggests that structural changes under pressure are interpretable as a shift in the populations of conformational substates. Furthermore, a novel high-pressure protein crystal-cooling method has been used to show low-temperature metastability, providing an alternative to room temperature, beryllium pressure cell-based techniques. The change in protein structure due to pressure is not purely compressive and involves conformational changes important to protein activity. Correlation with low-pH structures suggests observed structural changes are associated with global conformational substates. Methods developed here open up a direct avenue for exploration of the effects of pressure on proteins.
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{{STRUCTURE_1jp6| PDB=1jp6 | SCENE= }}
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Probing substates in sperm whale myoglobin using high-pressure crystallography.,Urayama P, Phillips GN Jr, Gruner SM Structure. 2002 Jan;10(1):51-60. PMID:11796110<ref>PMID:11796110</ref>
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===Sperm Whale met-Myoglobin (room temperature; room pressure)===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_11796110}}
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==About this Structure==
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[[1jp6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JP6 OCA].
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==See Also==
==See Also==
*[[Myoglobin|Myoglobin]]
*[[Myoglobin|Myoglobin]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011796110</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Physeter catodon]]
[[Category: Physeter catodon]]
[[Category: Gruner, S M.]]
[[Category: Gruner, S M.]]

Revision as of 12:44, 28 September 2014

Sperm Whale met-Myoglobin (room temperature; room pressure)

1jp6, resolution 2.30Å

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