1k6g
From Proteopedia
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| - | [[ | + | ==Solution Structure of Conserved AGNN Tetraloops: Insights into Rnt1p RNA Processing== |
| + | <StructureSection load='1k6g' size='340' side='right' caption='[[1k6g]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1k6g]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K6G FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1k6h|1k6h]]</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k6g RCSB], [http://www.ebi.ac.uk/pdbsum/1k6g PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Rnt1p, the yeast orthologue of RNase III, cleaves rRNAs, snRNAs and snoRNAs at a stem capped with conserved AGNN tetraloop. Here we show that 9 bp long stems ending with AGAA or AGUC tetraloops bind to Rnt1p and direct specific but sequence-independent RNA cleavage when provided with stems longer than 13 bp. The solution structures of these two tetraloops reveal a common fold for the terminal loop stabilized by non-canonical A-A or A-C pairs and extensive base stacking. The conserved nucleotides are stacked at the 5' side of the loop, exposing their Watson-Crick and Hoogsteen faces for recognition by Rnt1p. These results indicate that yeast RNase III recognizes the fold of a conserved single-stranded tetraloop to direct specific dsRNA cleavage. | ||
| - | + | Solution structure of conserved AGNN tetraloops: insights into Rnt1p RNA processing.,Lebars I, Lamontagne B, Yoshizawa S, Aboul-Elela S, Fourmy D EMBO J. 2001 Dec 17;20(24):7250-8. PMID:11743001<ref>PMID:11743001</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | == | + | |
| - | < | + | |
[[Category: Elela, S Abou.]] | [[Category: Elela, S Abou.]] | ||
[[Category: Fourmy, D.]] | [[Category: Fourmy, D.]] | ||
Revision as of 12:55, 28 September 2014
Solution Structure of Conserved AGNN Tetraloops: Insights into Rnt1p RNA Processing
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