1hr0
From Proteopedia
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| - | [[ | + | ==CRYSTAL STRUCTURE OF INITIATION FACTOR IF1 BOUND TO THE 30S RIBOSOMAL SUBUNIT== |
| + | <StructureSection load='1hr0' size='340' side='right' caption='[[1hr0]], [[Resolution|resolution]] 3.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1hr0]] is a 23 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HR0 FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br> | ||
| + | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qd7|1qd7]], [[1fjf|1fjf]], [[1fjg|1fjg]]</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hr0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hr0 RCSB], [http://www.ebi.ac.uk/pdbsum/1hr0 PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hr/1hr0_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Initiation of translation at the correct position on messenger RNA is essential for accurate protein synthesis. In prokaryotes, this process requires three initiation factors: IF1, IF2, and IF3. Here we report the crystal structure of a complex of IF1 and the 30S ribosomal subunit. Binding of IF1 occludes the ribosomal A site and flips out the functionally important bases A1492 and A1493 from helix 44 of 16S RNA, burying them in pockets in IF1. The binding of IF1 causes long-range changes in the conformation of H44 and leads to movement of the domains of 30S with respect to each other. The structure explains how localized changes at the ribosomal A site lead to global alterations in the conformation of the 30S subunit. | ||
| - | + | Crystal structure of an initiation factor bound to the 30S ribosomal subunit.,Carter AP, Clemons WM Jr, Brodersen DE, Morgan-Warren RJ, Hartsch T, Wimberly BT, Ramakrishnan V Science. 2001 Jan 19;291(5503):498-501. PMID:11228145<ref>PMID:11228145</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
| - | *[[Ribosomal protein S10|Ribosomal protein S10]] | ||
| - | *[[Ribosomal protein S11|Ribosomal protein S11]] | ||
| - | *[[Ribosomal protein S12|Ribosomal protein S12]] | ||
| - | *[[Ribosomal protein S13|Ribosomal protein S13]] | ||
| - | *[[Ribosomal protein S14|Ribosomal protein S14]] | ||
| - | *[[Ribosomal protein S15|Ribosomal protein S15]] | ||
| - | *[[Ribosomal protein S16|Ribosomal protein S16]] | ||
| - | *[[Ribosomal protein S17|Ribosomal protein S17]] | ||
| - | *[[Ribosomal protein S18|Ribosomal protein S18]] | ||
| - | *[[Ribosomal protein S19|Ribosomal protein S19]] | ||
| - | *[[Ribosomal protein S2|Ribosomal protein S2]] | ||
| - | *[[Ribosomal protein S20|Ribosomal protein S20]] | ||
| - | *[[Ribosomal protein S3|Ribosomal protein S3]] | ||
| - | *[[Ribosomal protein S4|Ribosomal protein S4]] | ||
| - | *[[Ribosomal protein S5|Ribosomal protein S5]] | ||
| - | *[[Ribosomal protein S6|Ribosomal protein S6]] | ||
| - | *[[Ribosomal protein S7|Ribosomal protein S7]] | ||
| - | *[[Ribosomal protein S8|Ribosomal protein S8]] | ||
| - | *[[Ribosomal protein S9|Ribosomal protein S9]] | ||
*[[Ribosomal protein THX|Ribosomal protein THX]] | *[[Ribosomal protein THX|Ribosomal protein THX]] | ||
| - | *[[Ribosome|Ribosome]] | + | *[[Ribosome 3D structures|Ribosome 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Thermus thermophilus]] | [[Category: Thermus thermophilus]] | ||
Revision as of 13:52, 28 September 2014
CRYSTAL STRUCTURE OF INITIATION FACTOR IF1 BOUND TO THE 30S RIBOSOMAL SUBUNIT
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