1f3h
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1f3h.gif|left|200px]] | + | [[Image:1f3h.gif|left|200px]] |
| - | + | ||
| - | '''X-RAY CRYSTAL STRUCTURE OF THE HUMAN ANTI-APOPTOTIC PROTEIN SURVIVIN''' | + | {{Structure |
| + | |PDB= 1f3h |SIZE=350|CAPTION= <scene name='initialview01'>1f3h</scene>, resolution 2.58Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''X-RAY CRYSTAL STRUCTURE OF THE HUMAN ANTI-APOPTOTIC PROTEIN SURVIVIN''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1F3H is a [ | + | 1F3H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F3H OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement., Verdecia MA, Huang H, Dutil E, Kaiser DA, Hunter T, Noel JP, Nat Struct Biol. 2000 Jul;7(7):602-8. PMID:[http:// | + | Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement., Verdecia MA, Huang H, Dutil E, Kaiser DA, Hunter T, Noel JP, Nat Struct Biol. 2000 Jul;7(7):602-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10876248 10876248] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 25: | Line 34: | ||
[[Category: thiol protease inhibitor]] | [[Category: thiol protease inhibitor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:03:58 2008'' |
Revision as of 09:03, 20 March 2008
| |||||||
| , resolution 2.58Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
X-RAY CRYSTAL STRUCTURE OF THE HUMAN ANTI-APOPTOTIC PROTEIN SURVIVIN
Overview
Survivin is a 16.5 kDa protein that is expressed during the G2/M phase of the cell cycle and is hypothesized to inhibit a default apoptotic cascade initiated in mitosis. This inhibitory function is coupled to survivin's localization to the mitotic spindle. To begin to address the structural basis of survivin's function, we report the X-ray crystal structure of a recombinant form of full length survivin to 2.58 A resolution. Survivin consists of two defined domains including an N-terminal Zn2+-binding BIR domain linked to a 65 A amphipathic C-terminal alpha-helix. The crystal structure reveals an extensive dimerization interface along a hydrophobic surface on the BIR domain of each survivin monomer. A basic patch acting as a sulfate/phosphate-binding module, an acidic cluster projecting off the BIR domain, and a solvent-accessible hydrophobic surface residing on the C-terminal amphipathic helix, are suggestive of functional protein-protein interaction surfaces.
About this Structure
1F3H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement., Verdecia MA, Huang H, Dutil E, Kaiser DA, Hunter T, Noel JP, Nat Struct Biol. 2000 Jul;7(7):602-8. PMID:10876248
Page seeded by OCA on Thu Mar 20 11:03:58 2008
