1f3m

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[[Image:1f3m.gif|left|200px]]<br /><applet load="1f3m" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1f3m.gif|left|200px]]
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caption="1f3m, resolution 2.3&Aring;" />
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'''CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1'''<br />
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{{Structure
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|PDB= 1f3m |SIZE=350|CAPTION= <scene name='initialview01'>1f3m</scene>, resolution 2.3&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=IOD:IODIDE ION'>IOD</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1F3M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=IOD:'>IOD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F3M OCA].
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1F3M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F3M OCA].
==Reference==
==Reference==
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Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch., Lei M, Lu W, Meng W, Parrini MC, Eck MJ, Mayer BJ, Harrison SC, Cell. 2000 Aug 4;102(3):387-97. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10975528 10975528]
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Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch., Lei M, Lu W, Meng W, Parrini MC, Eck MJ, Mayer BJ, Harrison SC, Cell. 2000 Aug 4;102(3):387-97. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10975528 10975528]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: kinase domain]]
[[Category: kinase domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:34:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:03:55 2008''

Revision as of 09:04, 20 March 2008

Image:1f3m.gif


PDB ID 1f3m

Drag the structure with the mouse to rotate
, resolution 2.3Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1


Overview

The p21-activated kinases (PAKs), stimulated by binding with GTP-liganded forms of Cdc42 or Rac, modulate cytoskeletal actin assembly and activate MAP-kinase pathways. The 2.3 A resolution crystal structure of a complex between the N-terminal autoregulatory fragment and the C-terminal kinase domain of PAK1 shows that GTPase binding will trigger a series of conformational changes, beginning with disruption of a PAK1 dimer and ending with rearrangement of the kinase active site into a catalytically competent state. An inhibitory switch (IS) domain, which overlaps the GTPase binding region of PAK1, positions a polypeptide segment across the kinase cleft. GTPase binding will refold part of the IS domain and unfold the rest. A related switch has been seen in the Wiskott-Aldrich syndrome protein (WASP).

About this Structure

1F3M is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch., Lei M, Lu W, Meng W, Parrini MC, Eck MJ, Mayer BJ, Harrison SC, Cell. 2000 Aug 4;102(3):387-97. PMID:10975528

Page seeded by OCA on Thu Mar 20 11:03:55 2008

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