1gqu

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[[Image:1gqu.png|left|200px]]
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==CRYSTAL STRUCTURE OF AN ALTERNATING A-T OLIGONUCLEOTIDE FRAGMENT WITH HOOGSTEEN BASE PAIRING==
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<StructureSection load='1gqu' size='340' side='right' caption='[[1gqu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1gqu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GQU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GQU FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BRU:5-BROMO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BRU</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gqu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gqu RCSB], [http://www.ebi.ac.uk/pdbsum/1gqu PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report here an alternative double-helical structure of the DNA molecule. It has been found in the d(ATA(Br)UAT) and d(ATATAT) sequences by single-crystal x-ray crystallography. This sequence is found not only in TATA boxes, but also in other regulatory regions of DNA. Bases of the two antiparallel strands form Hoogsteen pairs, with adenines in the syn conformation. The structure is related neither to those found in triple helices nor to parallel DNA duplexes. Its conformational parameters are very similar to those of duplex DNA in the B form. Both forms may coexist under physiological conditions, although the Hoogsteen pairing greatly influences the recognition sites on DNA. Our results demonstrate that an alternative to the classical B-DNA double helix is possible.
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{{STRUCTURE_1gqu| PDB=1gqu | SCENE= }}
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Crystal structure of an antiparallel DNA fragment with Hoogsteen base pairing.,Abrescia NG, Thompson A, Huynh-Dinh T, Subirana JA Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2806-11. PMID:11880632<ref>PMID:11880632</ref>
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===CRYSTAL STRUCTURE OF AN ALTERNATING A-T OLIGONUCLEOTIDE FRAGMENT WITH HOOGSTEEN BASE PAIRING===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_11880632}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1gqu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GQU OCA].
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</StructureSection>
[[Category: Abrescia, N G.A.]]
[[Category: Abrescia, N G.A.]]
[[Category: Huynh-Dinh, T.]]
[[Category: Huynh-Dinh, T.]]

Revision as of 14:00, 28 September 2014

CRYSTAL STRUCTURE OF AN ALTERNATING A-T OLIGONUCLEOTIDE FRAGMENT WITH HOOGSTEEN BASE PAIRING

1gqu, resolution 2.50Å

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