1f42

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[[Image:1f42.gif|left|200px]]<br /><applet load="1f42" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1f42.gif|left|200px]]
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caption="1f42, resolution 2.5&Aring;" />
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'''THE P40 DOMAIN OF HUMAN INTERLEUKIN-12'''<br />
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{{Structure
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|PDB= 1f42 |SIZE=350|CAPTION= <scene name='initialview01'>1f42</scene>, resolution 2.5&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MNB:5-MERCAPTO-2-NITRO-BENZOIC ACID'>MNB</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''THE P40 DOMAIN OF HUMAN INTERLEUKIN-12'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1F42 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MNB:'>MNB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F42 OCA].
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1F42 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F42 OCA].
==Reference==
==Reference==
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Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12., Yoon C, Johnston SC, Tang J, Stahl M, Tobin JF, Somers WS, EMBO J. 2000 Jul 17;19(14):3530-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10899108 10899108]
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Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12., Yoon C, Johnston SC, Tang J, Stahl M, Tobin JF, Somers WS, EMBO J. 2000 Jul 17;19(14):3530-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10899108 10899108]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: cytokine]]
[[Category: cytokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:34:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:04:04 2008''

Revision as of 09:04, 20 March 2008

Image:1f42.gif


PDB ID 1f42

Drag the structure with the mouse to rotate
, resolution 2.5Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



THE P40 DOMAIN OF HUMAN INTERLEUKIN-12


Contents

Overview

Human interleukin-12 (IL-12, p70) is an early pro-inflammatory cytokine, comprising two disulfide-linked subunits, p35 and p40. We solved the crystal structures of monomeric human p40 at 2.5 A and the human p70 complex at 2.8 A resolution, which reveals that IL-12 is similar to class 1 cytokine-receptor complexes. They also include the first description of an N-terminal immunoglobulin-like domain, found on the p40 subunit. Several charged residues from p35 and p40 intercalate to form a unique interlocking topography, shown by mutagenesis to be critical for p70 formation. A central arginine residue from p35 projects into a deep pocket on p40, which may be an ideal target for a small molecule antagonist of IL-12 formation.

Disease

Known diseases associated with this structure: Asthma, susceptibility to OMIM:[161561], BCG and salmonella infection, disseminated OMIM:[161561], Psoriasis, susceptibility to OMIM:[161561]

About this Structure

1F42 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12., Yoon C, Johnston SC, Tang J, Stahl M, Tobin JF, Somers WS, EMBO J. 2000 Jul 17;19(14):3530-41. PMID:10899108

Page seeded by OCA on Thu Mar 20 11:04:04 2008

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