1f3u
From Proteopedia
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| - | [[Image:1f3u.jpg|left|200px]] | + | [[Image:1f3u.jpg|left|200px]] |
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| - | '''CRYSTAL STRUCTURE OF THE RAP30/74 INTERACTION DOMAINS OF HUMAN TFIIF''' | + | {{Structure |
| + | |PDB= 1f3u |SIZE=350|CAPTION= <scene name='initialview01'>1f3u</scene>, resolution 1.70Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''CRYSTAL STRUCTURE OF THE RAP30/74 INTERACTION DOMAINS OF HUMAN TFIIF''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1F3U is a [ | + | 1F3U is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F3U OCA]. |
==Reference== | ==Reference== | ||
| - | Novel dimerization fold of RAP30/RAP74 in human TFIIF at 1.7 A resolution., Gaiser F, Tan S, Richmond TJ, J Mol Biol. 2000 Oct 6;302(5):1119-27. PMID:[http:// | + | Novel dimerization fold of RAP30/RAP74 in human TFIIF at 1.7 A resolution., Gaiser F, Tan S, Richmond TJ, J Mol Biol. 2000 Oct 6;302(5):1119-27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11183778 11183778] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: rna polymerase ii]] | [[Category: rna polymerase ii]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:04:04 2008'' |
Revision as of 09:04, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF THE RAP30/74 INTERACTION DOMAINS OF HUMAN TFIIF
Overview
General transcription factor IIF (TFIIF) is required for transcription by RNA polymerase II; it consists minimally of a heterodimer of RNA polymerase-associated proteins RAP30 and RAP74. According to solution and mutagenesis studies, the multiple domains of RAP30 and RAP74 bind PolII, TFIIB, TAF250 and DNA in interactions that are essential for transcription initiation and elongation. The X-ray structure of the RAP30/RAP74 interaction domains at 1.7 A resolution reveals a novel "triple barrel" dimerization fold and suggests with mutant data that interactions with the transcription apparatus are mediated not only by this tripartite beta-barrel, but also via flexible loops and alpha and beta-structures extending from it.
About this Structure
1F3U is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Novel dimerization fold of RAP30/RAP74 in human TFIIF at 1.7 A resolution., Gaiser F, Tan S, Richmond TJ, J Mol Biol. 2000 Oct 6;302(5):1119-27. PMID:11183778
Page seeded by OCA on Thu Mar 20 11:04:04 2008
