1o0k

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[[Image:1o0k.png|left|200px]]
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==Structure of the First Parallel DNA Quadruplex-drug Complex==
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<StructureSection load='1o0k' size='340' side='right' caption='[[1o0k]], [[Resolution|resolution]] 1.17&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1o0k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O0K FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DM1:DAUNOMYCIN'>DM1</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o0k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o0k RCSB], [http://www.ebi.ac.uk/pdbsum/1o0k PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The first crystal structure of a drug (daunomycin) bound to a parallel-stranded intermolecular telomeric G4 quadruplex (d(TGGGGT)4) has been determined to high resolution. A planar assemblage of three daunomycin molecules stacks onto the 5' end of the G4 column, with the daunosamine substituents occupying three of the four quadruplex grooves. The surface area of the terminal G-quartet in this parallel DNA quadruplex, presently occupied by three daunomycins, is sufficiently large that it could easily accommodate other potential telomerase inhibitors such as substituted porphyrins or telomestatin.
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{{STRUCTURE_1o0k| PDB=1o0k | SCENE= }}
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Structure of the first parallel DNA quadruplex-drug complex.,Clark GR, Pytel PD, Squire CJ, Neidle S J Am Chem Soc. 2003 Apr 9;125(14):4066-7. PMID:12670225<ref>PMID:12670225</ref>
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===Structure of the First Parallel DNA Quadruplex-drug Complex===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_12670225}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1o0k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O0K OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:012670225</ref><references group="xtra"/>
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[[Category: Clark, G R.]]
[[Category: Clark, G R.]]
[[Category: Neidle, S.]]
[[Category: Neidle, S.]]

Revision as of 14:02, 28 September 2014

Structure of the First Parallel DNA Quadruplex-drug Complex

1o0k, resolution 1.17Å

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