1f59

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[[Image:1f59.gif|left|200px]]<br /><applet load="1f59" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1f59.gif|left|200px]]
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caption="1f59, resolution 2.8&Aring;" />
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'''IMPORTIN-BETA-FXFG NUCLEOPORIN COMPLEX'''<br />
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{{Structure
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|PDB= 1f59 |SIZE=350|CAPTION= <scene name='initialview01'>1f59</scene>, resolution 2.8&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''IMPORTIN-BETA-FXFG NUCLEOPORIN COMPLEX'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1F59 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F59 OCA].
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1F59 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F59 OCA].
==Reference==
==Reference==
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Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking., Bayliss R, Littlewood T, Stewart M, Cell. 2000 Jul 7;102(1):99-108. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10929717 10929717]
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Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking., Bayliss R, Littlewood T, Stewart M, Cell. 2000 Jul 7;102(1):99-108. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10929717 10929717]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: protein-protein complex]]
[[Category: protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:35:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:04:36 2008''

Revision as of 09:04, 20 March 2008

Image:1f59.gif


PDB ID 1f59

Drag the structure with the mouse to rotate
, resolution 2.8Å
Coordinates: save as pdb, mmCIF, xml



IMPORTIN-BETA-FXFG NUCLEOPORIN COMPLEX


Overview

We describe the crystal structure of a complex between importin-beta residues 1-442 (Ib442) and five FxFG nucleoporin repeats from Nsp1p. Nucleoporin FxFG cores bind on the convex face of Ib442 to a primary site between the A helices of HEAT repeats 5 and 6, and to a secondary site between HEAT repeats 6 and 7. Mutations at importin-beta Ile178 in the primary FxFG binding site reduce both binding and nuclear protein import, providing direct evidence for the functional significance of the importin-beta-FxFG interaction. The FxFG binding sites on importin-beta do not overlap with the RanGTP binding site. Instead, RanGTP may release importin-beta from FxFG nucleoporins by generating a conformational change that alters the structure of the FxFG binding site.

About this Structure

1F59 is a Single protein structure of sequence from Homo sapiens and Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking., Bayliss R, Littlewood T, Stewart M, Cell. 2000 Jul 7;102(1):99-108. PMID:10929717

Page seeded by OCA on Thu Mar 20 11:04:36 2008

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