1lq7
From Proteopedia
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| - | [[ | + | ==De Novo Designed Protein Model of Radical Enzymes== |
| + | <StructureSection load='1lq7' size='340' side='right' caption='[[1lq7]], [[NMR_Ensembles_of_Models | 16 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1lq7]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LQ7 FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lq7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lq7 RCSB], [http://www.ebi.ac.uk/pdbsum/1lq7 PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The use of side chains as catalytic cofactors for protein mediated redox chemistry raises significant mechanistic issues as to how these amino acids are activated toward radical chemistry in a controlled manner. De novo protein design has been used to examine the structural basis for the creation and maintenance of a tryptophanyl radical in a three-helix bundle protein maquette. Here we report the detailed structural analysis of the protein by multidimensional NMR methods. An interesting feature of the structure is an apparent pi-cation interaction involving the sole tryptophan and a lysine side chain. Hybrid density functional calculations support the notion that this interaction raises the reduction potential of the W degrees /WH redox pair and helps explain the redox characteristics of the protein. This model protein system therefore provides a powerful model for exploring the structural basis for controlled radical chemistry in protein. | ||
| - | + | Structure of a de novo designed protein model of radical enzymes.,Dai QH, Tommos C, Fuentes EJ, Blomberg MR, Dutton PL, Wand AJ J Am Chem Soc. 2002 Sep 18;124(37):10952-3. PMID:12224922<ref>PMID:12224922</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | + | </StructureSection> | |
[[Category: Blomberg, M.]] | [[Category: Blomberg, M.]] | ||
[[Category: Dai, Q H.]] | [[Category: Dai, Q H.]] | ||
Revision as of 14:48, 28 September 2014
De Novo Designed Protein Model of Radical Enzymes
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