2ix0

From Proteopedia

Revision as of 15:13, 30 October 2007

RNASE II

Overview

RNA degradation is a determining factor in the control of gene expression., The maturation, turnover and quality control of RNA is performed by many, different classes of ribonucleases. Ribonuclease II (RNase II) is a major, exoribonuclease that intervenes in all of these fundamental processes; it, can act independently or as a component of the exosome, an essential, RNA-degrading multiprotein complex. RNase II-like enzymes are found in all, three kingdoms of life, but there are no structural data for any of the, proteins of this family. Here we report the X-ray crystallographic, structures of both the ligand-free (at 2.44 A resolution) and RNA-bound, (at 2.74 A resolution) forms of Escherichia coli RNase II. In contrast to, sequence predictions, the structures show that RNase II is ... [(full description)]

About this Structure

2IX0 is a [Single protein] structure of sequence from [Escherichia coli] with MG, CA and C5P as [ligands]. Active as [Exoribonuclease II], with EC number [3.1.13.1]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Unravelling the dynamics of RNA degradation by ribonuclease II and its RNA-bound complex., Frazao C, McVey CE, Amblar M, Barbas A, Vonrhein C, Arraiano CM, Carrondo MA, Nature. 2006 Sep 7;443(7107):110-4. PMID:16957732

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