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1lgy

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[[Image:1lgy.png|left|200px]]
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==LIPASE II FROM RHIZOPUS NIVEUS==
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<StructureSection load='1lgy' size='340' side='right' caption='[[1lgy]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1lgy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhizopus_niveus Rhizopus niveus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LGY FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lgy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lgy RCSB], [http://www.ebi.ac.uk/pdbsum/1lgy PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lg/1lgy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal and molecular structure of Lipase II from Rhizopus niveus was analyzed using X-ray single crystal diffraction data at a resolution of 2.2 A. The structure was refined to an R-factor of 0.19 for all available data. This lipase was purified and crystallized as Lipase I, which contains two polypeptide chains combined through non-covalent interaction. However, during crystal growth, Lipase I was converted to Lipase II, which consists of a single polypeptide chain of 269 amino acid residues, by limited proteolysis. The structure of Lipase II shows a typical alpha/beta hydrolase fold containing the so-called nucleophilic elbow. The catalytic center of this enzyme is analogous to those of other neutral lipases and serine proteases. This catalytic center is sheltered by an alpha-helix lid, which appears in neutral lipases, opening the active site at the oil-water interface.
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{{STRUCTURE_1lgy| PDB=1lgy | SCENE= }}
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The crystal structure of lipase II from Rhizopus niveus at 2.2 A resolution.,Kohno M, Funatsu J, Mikami B, Kugimiya W, Matsuo T, Morita Y J Biochem. 1996 Sep;120(3):505-10. PMID:8902613<ref>PMID:8902613</ref>
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===LIPASE II FROM RHIZOPUS NIVEUS===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_8902613}}
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==About this Structure==
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[[1lgy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhizopus_niveus Rhizopus niveus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LGY OCA].
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==See Also==
==See Also==
*[[Lipase|Lipase]]
*[[Lipase|Lipase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:008902613</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Rhizopus niveus]]
[[Category: Rhizopus niveus]]
[[Category: Triacylglycerol lipase]]
[[Category: Triacylglycerol lipase]]

Revision as of 15:15, 28 September 2014

LIPASE II FROM RHIZOPUS NIVEUS

1lgy, resolution 2.20Å

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