1fat

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[[Image:1fat.gif|left|200px]]<br /><applet load="1fat" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1fat.gif|left|200px]]
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caption="1fat, resolution 2.8&Aring;" />
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'''PHYTOHEMAGGLUTININ-L'''<br />
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{{Structure
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|PDB= 1fat |SIZE=350|CAPTION= <scene name='initialview01'>1fat</scene>, resolution 2.8&Aring;
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|SITE= <scene name='pdbsite=CAA:Ca+Binding+Site+In+Chain+A'>CAA</scene>, <scene name='pdbsite=CAB:Ca+Binding+Site+In+Chain+B'>CAB</scene>, <scene name='pdbsite=CAC:Ca+Binding+Site+In+Chain+C'>CAC</scene>, <scene name='pdbsite=CAD:Ca+Binding+Site+In+Chain+D'>CAD</scene>, <scene name='pdbsite=MNA:Mn+Binding+Site+In+Chain+A'>MNA</scene>, <scene name='pdbsite=MNB:Mn+Binding+Site+In+Chain+B'>MNB</scene>, <scene name='pdbsite=MNC:Mn+Binding+Site+In+Chain+C'>MNC</scene> and <scene name='pdbsite=MND:Mn+Binding+Site+In+Chain+D'>MND</scene>
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''PHYTOHEMAGGLUTININ-L'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1FAT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Phaseolus_vulgaris Phaseolus vulgaris] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=MN:'>MN</scene> and <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=CAA:Ca+Binding+Site+In+Chain+A'>CAA</scene>, <scene name='pdbsite=CAB:Ca+Binding+Site+In+Chain+B'>CAB</scene>, <scene name='pdbsite=CAC:Ca+Binding+Site+In+Chain+C'>CAC</scene>, <scene name='pdbsite=CAD:Ca+Binding+Site+In+Chain+D'>CAD</scene>, <scene name='pdbsite=MNA:Mn+Binding+Site+In+Chain+A'>MNA</scene>, <scene name='pdbsite=MNB:Mn+Binding+Site+In+Chain+B'>MNB</scene>, <scene name='pdbsite=MNC:Mn+Binding+Site+In+Chain+C'>MNC</scene> and <scene name='pdbsite=MND:Mn+Binding+Site+In+Chain+D'>MND</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FAT OCA].
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1FAT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Phaseolus_vulgaris Phaseolus vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FAT OCA].
==Reference==
==Reference==
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The crystallographic structure of phytohemagglutinin-L., Hamelryck TW, Dao-Thi MH, Poortmans F, Chrispeels MJ, Wyns L, Loris R, J Biol Chem. 1996 Aug 23;271(34):20479-85. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8702788 8702788]
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The crystallographic structure of phytohemagglutinin-L., Hamelryck TW, Dao-Thi MH, Poortmans F, Chrispeels MJ, Wyns L, Loris R, J Biol Chem. 1996 Aug 23;271(34):20479-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8702788 8702788]
[[Category: Phaseolus vulgaris]]
[[Category: Phaseolus vulgaris]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: plant defense protein]]
[[Category: plant defense protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:36:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:06:41 2008''

Revision as of 09:06, 20 March 2008

Image:1fat.gif


PDB ID 1fat

Drag the structure with the mouse to rotate
, resolution 2.8Å
Sites: , , , , , , and
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



PHYTOHEMAGGLUTININ-L


Overview

The structure of phytohemagglutinin-L (PHA-L), a leucoagglutinating seed lectin from Phaseolus vulgaris, has been solved with molecular replacement using the coordinates of lentil lectin as model, and refined at a resolution of 2.8 A. The final R-factor of the structure is 20.0%. The quaternary structure of the PHA-L tetramer differs from the structures of the concanavalin A and peanut lectin tetramers, but resembles the structure of the soybean agglutinin tetramer. PHA-L consists of two canonical legume lectin dimers that pack together through the formation of a close contact between two beta-strands. Of the two covalently bound oligosaccharides per monomer, only one GlcNAc residue per monomer is visible in the electron density. In this article we describe the structure of PHA-L, and we discuss the putative position of the high affinity adenine-binding site present in a number of legume lectins. A comparison with transthyretin, a protein that shows a remarkable resemblance to PHA-L, gives further ground to our proposal.

About this Structure

1FAT is a Single protein structure of sequence from Phaseolus vulgaris. Full crystallographic information is available from OCA.

Reference

The crystallographic structure of phytohemagglutinin-L., Hamelryck TW, Dao-Thi MH, Poortmans F, Chrispeels MJ, Wyns L, Loris R, J Biol Chem. 1996 Aug 23;271(34):20479-85. PMID:8702788

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